TSC22D3 Protein (His tag)
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- Target Alle TSC22D3 Proteine anzeigen
- TSC22D3 (TSC22 Domain Family, Member 3 (TSC22D3))
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses TSC22D3 Protein ist gelabelt mit His tag.
- Applikation
- SDS-PAGE (SDS)
- Aufreinigung
- purified by chromatography
- Reinheit
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product TSC22D3 Protein
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- Kommentare
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Synonyms: TSC22 domain family protein 3, DIP, DSIPI, GILZ, hDIP, TSC-22R
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 10% glycerol, 1 MM DTT
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Avoid repeated freezing and thawing cycles.
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- Target
- TSC22D3 (TSC22 Domain Family, Member 3 (TSC22D3))
- Andere Bezeichnung
- TSC22D3 (TSC22D3 Produkte)
- Synonyme
- dsipi Protein, MGC53285 Protein, zgc:65831 Protein, zgc:77028 Protein, TSC22D3 Protein, GILZ Protein, gilz Protein, tsc-22r Protein, DIP Protein, DSIPI Protein, TSC-22R Protein, hDIP Protein, Dsip1 Protein, Gilz Protein, Tilz3 Protein, Dsipi Protein, DSIP Protein, TSC22 domain family member 3 L homeolog Protein, TSC22 domain family, member 3 Protein, TSC22 domain family member 3 Protein, tsc22d3.L Protein, tsc22d3 Protein, TSC22D3 Protein, Tsc22d3 Protein
- Hintergrund
- TSC22 domain family protein 3, also known as TSC22D3, protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, TSC22D3 plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, TSC22D3 inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Recombinant human TSC22D3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molekulargewicht
- 17.2 kDa (157aa) confirmed by MALDI-TOF
- NCBI Accession
- NP_004080
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