MCL-1 Protein (His tag)

Produktnummer ABIN1098214

Produktdetails

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses MCL-1 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Aufreinigung: purified by chromatography

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Kommentare:

Synonyms: induced myeloid leukemia cell differentiation protein Mcl-1, BCL2L3, mcl1/EAT, myeloid cell leukemia sequence 1, Bcl-2-like protein 3

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 20% glycerol, 2 mM DTT

Lagerung: 4 °C

Informationen zur Lagerung: Avoid repeated freezing and thawing cycles.

Antigendetails

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Andere Bezeichnung: MCL1 (MCL1 Produkte)

Synonyme: BCL2L3 Protein, EAT Protein, MCL1-ES Protein, MCL1L Protein, MCL1S Protein, Mcl-1 Protein, TM Protein, bcl2-L-3 Protein, mcl1/EAT Protein, AW556805 Protein, mcl-1 Protein, fb72f02 Protein, wu:fb70a08 Protein, wu:fb72f02 Protein, zfMLP1 Protein, zfMcl-1a Protein, zgc:109835 Protein, zgc:109763 Protein, E3 Protein, E3-2 Protein, RNE3 Protein, RNU107 Protein, SNORA63A Protein, elF-4AII Protein, MCL1, BCL2 family apoptosis regulator Protein, myeloid cell leukemia sequence 1 Protein, MCL1, BCL2 family apoptosis regulator a Protein, MCL1, BCL2 family apoptosis regulator b Protein, small nucleolar RNA, H/ACA box 63 Protein, MCL1 Protein, Mcl1 Protein, mcl1a Protein, mcl1b Protein, SNORA63 Protein

Hintergrund: MCL1, also known as BCL2L3, belongs to the Bcl-2 family. MCL1 is involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. Recombinant human MCL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques

Molekulargewicht: 37.2 kDa (347aa), confirmed by MALDI-TOF

NCBI Accession: NP_068779

Pathways: MAPK Signalweg