SPINK4 Protein (AA 27-86) (His tag)

Produktnummer ABIN1097577

Produktdetails

Target: SPINK4 (Serine Peptidase Inhibitor, Kazal Type 4 (SPINK4))

Protein-Typ: Recombinant

Proteineigenschaft: AA 27-86

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses SPINK4 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Serpin Kazal-4/SPINK4 (C-6His)

Sequenz: GKLPFSRMPI CEHMVESPTC SQMSNLVCGT DGLTYTNECQ LCLARIKTKQ DIQIMKDGKC VDHHHHHH

Produktmerkmale: Recombinant Human Serine Protease Inhibitor Kazal-Type 4/SPINK4 produced by transfected human cells is a secreted protein with sequence (Gly27-Cys86) of human SPINK4 fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, 2 mM CaCl2, 1 mM DTT, 0.05 % Brij35, 10 % Glycerol, pH 6.0.

Konservierungsmittel: Dithiothreitol (DTT)

Vorsichtsmaßnahmen: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: -80 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: SPINK4 (Serine Peptidase Inhibitor, Kazal Type 4 (SPINK4))

Andere Bezeichnung: spink4 (SPINK4 Produkte)

Synonyme: PEC-60 Protein, PEC60 Protein, MPGC60 Protein, serine peptidase inhibitor, Kazal type 4 Protein, SPINK4 Protein, Spink4 Protein

Sub Type: Fusionprotein

Hintergrund: Serine Protease Inhibitor Kazal-Type 4 (SPINK4) is a secreted protein containing one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activity. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK9 was identified in human skin. Its expression was strong in palmar epidermis, but not detectable or very low in non palmoplantar skin.
Alternative Names: Serine Protease Inhibitor Kazal-Type 4, Peptide PEC-60 Homolog, SPINK4

Molekulargewicht: 7.73 kDa

UniProt: O60575