Tumor Necrosis Factor (TNF) (AA 78-234) protein (His tag)

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Proteinname
  • TNF
  • tnf
  • dif
  • tnfa
  • xtnf
  • TNF-a
  • tnfsf2
  • tnf-alpha
  • TNF-alpha
  • DIF
  • TNFA
  • TNFSF2
  • TNFalpha
  • Tnfa
  • Tnfsf1a
  • RATTNF
  • TNFa
  • cTNF
  • TNF-ALPHA
  • Cachectin
  • Tnf-alpha
  • tnfa-like
  • tumor necrosis factor (TNF superfamily, member 2)
  • tumor necrosis factor
  • tumour necrosis factor alpha-like
  • tumor necrosis factor alpha
  • lipopolysaccharide-induced TNF factor
  • tumor necrosis factor b (TNF superfamily, member 2)
  • TNF
  • tnf
  • tnf-alpha
  • LITAF
  • Tnf
  • tnfb
Proteineigenschaft
AA 78-234
28
13
12
7
7
5
5
5
4
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Spezies
Rind (Kuh)
115
50
29
8
6
5
5
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Quelle
Escherichia coli (E. coli)
155
26
16
6
4
3
3
2
2
2
2
1
1
Protein-Typ
Recombinant
Aufreinigungstag / Konjugat
Dieses Tumor Necrosis Factor Protein ist gelabelt mit His tag.
Applikation
SDS-PAGE (SDS), ELISA
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Sequenz LRSSSQASSN KPVAHVVADI NSPGQLRWWD SYANALMANG VKLEDNQLVV PADGLYLIYS QVLFRGQGCP STPLFLTHTI SRIAVSYQTK VNILSAIKSP CHRETPEWAE AKPWYEPIYQ GGVFQLEKGD RLSAEINLPD YLDYAESGQV YFGIIAL
Produktmerkmale Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Reinheit 95 %
Hintergrund Synonyms: Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a
Molekulargewicht 21.5 kD
UniProt Q06599
Pathways NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus
Kommentare

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer 20mM Tris-Hcl, 0.5M NaCl, 10% glycerin, PH 8.0, 200 mM Imidazole
Lagerung -20 °C
Bilder des Herstellers
SDS-PAGE (SDS) image for Tumor Necrosis Factor (TNF) (AA 78-234) protein (His tag) (ABIN1047829) Tumor Necrosis Factor (TNF) (AA 78-234) protein (His tag)
Allgemeine Veröffentlichungen Dietz, Neibergs, Womack, Kehrli: "Rapid communication: single strand conformational polymorphism (SSCP) of bovine tumor necrosis factor alpha." in: Journal of animal science, Vol. 75, Issue 9, pp. 2567, 1997 (PubMed).

Mertens, Muriuki, Gaidulis: "Cloning of two members of the TNF-superfamily in cattle: CD40 ligand and tumor necrosis factor alpha." in: Immunogenetics, Vol. 42, Issue 5, pp. 430-1, 1995 (PubMed).

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