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TNF alpha Protein (AA 77-233) (His tag)

TNF alpha Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant 90 % ELISA
Produktnummer ABIN1047825
  • Target Alle TNF alpha Proteine anzeigen
    TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 77-233
    Spezies
    • 43
    • 24
    • 12
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 61
    • 28
    • 23
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses TNF alpha Protein ist gelabelt mit His tag.
    Applikation
    ELISA
    Sequenz
    VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL
    Produktmerkmale
    Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.
    Reinheit
    90 %
    Top Product
    Discover our top product TNF alpha Protein
  • Kommentare

    The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Konzentration
    0.2-2 mg/mL
    Buffer
    Tris-based buffer, 50 % glycerol
    Handhabung
    Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C for extended storage, conserve at -20 °C or -80 °C
  • Nedospasov, Shakhov, Turetskaya, Mett, Azizov, Georgiev, Korobko, Dobrynin, Filippov, Bystrov: "Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome." in: Cold Spring Harbor symposia on quantitative biology, Vol. 51 Pt 1, pp. 611-24, (1987) (PubMed).

    Pennica, Nedwin, Hayflick, Seeburg, Derynck, Palladino, Kohr, Aggarwal, Goeddel: "Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin." in: Nature, Vol. 312, Issue 5996, pp. 724-9, (1985) (PubMed).

    Wang, Creasey, Ladner, Lin, Strickler, Van Arsdell, Yamamoto, Mark: "Molecular cloning of the complementary DNA for human tumor necrosis factor." in: Science (New York, N.Y.), Vol. 228, Issue 4696, pp. 149-54, (1985) (PubMed).

    Nedwin, Naylor, Sakaguchi, Smith, Jarrett-Nedwin, Pennica, Goeddel, Gray: "Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization." in: Nucleic acids research, Vol. 13, Issue 17, pp. 6361-73, (1985) (PubMed).

  • Target
    TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))
    Andere Bezeichnung
    Tumor necrosis factor protein (TNF alpha Produkte)
    Synonyme
    DIF Protein, TNF-alpha Protein, TNFA Protein, TNFSF2 Protein, RATTNF Protein, Tnfa Protein, tnf Protein, TNF-a Protein, TNFalpha Protein, Tnfsf1a Protein, TNFa Protein, cTNF Protein, Tnf-alpha Protein, tnfa-like Protein, TNF-ALPHA Protein, dif Protein, tnfa Protein, xtnf Protein, tnfsf2 Protein, tnf-alpha Protein, Cachectin Protein, tumor necrosis factor Protein, tumor necrosis factor b (TNF superfamily, member 2) Protein, tumor necrosis factor alpha Protein, tumor necrosis factor a (TNF superfamily, member 2) Protein, TNF Protein, Tnf Protein, tnf Protein, tnfb Protein, tnf-alpha Protein, LOC103694380 Protein, tnfa Protein
    Hintergrund
    Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
    Molekulargewicht
    21.4 kD
    UniProt
    P01375
    Pathways
    NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Inflammasome
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