TIMP2 Protein (AA 30-220, partial) (GST tag)

Produktnummer ABIN1095681

Produktdetails

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 30-220, partial

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses TIMP2 Protein ist gelabelt mit GST tag.

Applikation: ELISA

Sequenz: SPVHPQQAFC NADVVIRAKA VSEKEVDSGN DIYGNPIKRI QYEIKQIKMF KGPEKDIEFI YTAPSSAVCG VSLDVGGKKE YLIAGKAEGD GKMHITLCDF IVPWDTLSTT QKKSLNHRYQ MGCECKITRC PMIPCYISSP DECLWMDWVT EKNINGHQAK FFACIKRSDG SCAWYRGAAP PKQEFLDIED P

Produktmerkmale: Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.

Reinheit: 90 %

Anwendungsinformationen

Kommentare:

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: 0.2-2 mg/mL

Buffer: Tris-based buffer, 50 % glycerol

Handhabung: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C for extended storage, conserve at -20 °C or -80 °C

Referenzen

Stetler-Stevenson, Brown, Onisto, Levy, Liotta: "Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues." in: The Journal of biological chemistry, Vol. 265, Issue 23, pp. 13933-8, (1990) (PubMed).

Boone, Johnson, De Clerck, Langley: "cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 7, pp. 2800-4, (1990) (PubMed).

Antigendetails

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Andere Bezeichnung: Metalloproteinase inhibitor 2 protein (TIMP2 Produkte)

Synonyme: CSC-21K Protein, DDC8 Protein, timp2l Protein, zgc:65967 Protein, zgc:85799 Protein, D11Bwg1104e Protein, Timp-2 Protein, TIMP-2 Protein, etID32613.12 Protein, fa96h09 Protein, timp2 Protein, wu:fa96h09 Protein, zgc:136726 Protein, TIMP metallopeptidase inhibitor 2 Protein, TIMP metallopeptidase inhibitor 2b Protein, tissue inhibitor of metalloproteinase 2 Protein, TIMP metallopeptidase inhibitor 2a Protein, TIMP metallopeptidase inhibitor 2 L homeolog Protein, TIMP2 Protein, timp2b Protein, Timp2 Protein, timp2a Protein, timp2.L Protein

Hintergrund: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

Molekulargewicht: 48.8 kD

UniProt: P16035

Pathways: cAMP Metabolic Process