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Introduction of nuclear pore protein 160 (Nup160) from Drosophila simulans into Drosophila melanogaster caused female sterility in homozygous or hemizygous progeny.
While the distribution patterns of both lamins closely paralleled the respective stages of mitosis, Nup160 localization in metaphase oocytes corresponded to that in mitotic prometaphase rather than metaphase.
Nup107 (zeige NUP107 ELISA Kits)-160 complex and its partner Elys dynamically colocalize with Nup98 (zeige NUP98 ELISA Kits) and CRM1 (zeige XPO1 ELISA Kits) into endogenous GLFG bodies present in specific HeLa sublines.
transcriptome sequencing of patient-derived angiosarcoma cells, identified a novel fusion gene NUP160-SLC43A3 found to be expressed in 9 of 25 human angiosarcoma specimens that were examined.
The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex.
The interactions of Nup160 with Pom121 (zeige POM121 ELISA Kits) and are predicted to assist in the formation of the nuclear pore and the anchoring of the Nuclear pore complexes to the pore membrane.
A major function of the Nup107 (zeige NUP107 ELISA Kits) complex in mitosis is to ensure the proper localization of the chromosome passenger complex at the centromere.
Data show that Nup107 (zeige NUP107 ELISA Kits)-160 promotes spindle assembly through Ran-GTP (zeige AK3 ELISA Kits)-regulated nucleation of microtubules by gamma-TuRC at kinetochores, and reveal a relationship between nucleoporins and the microtubule cytoskeleton.
Data show that structure-guided sequence comparison of Nup160 and Saccharomyces cerevisiae Nup120 strongly suggests that both proteins adopt the same unique fold despite a low sequence identity of 10%.
Nup107 (zeige NUP107 ELISA Kits)-160 complex is dynamic in mitosis and that it promotes spindle assembly in a manner that is distinct from its functions at interphase nuclear pores.
phosphorylation does not affect interactions within the Nup107 (zeige NUP107 ELISA Kits)-160 subcomplex, but regulates the association of the subcomplex with the NPC (zeige NPC1 ELISA Kits) and other proteins
These data thus provide the first molecular clues underlying the function of the human Nup107 (zeige NUP107 ELISA Kits)-160 complex at kinetochores.
NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.
nuclear pore complex protein Nup160-like
, lethal (2) SH2055
, nuclear pore protein 160
, nucleoporin 160
, nucleoporin 160kDa
, nuclear pore complex protein Nup160
, 160 kDa nucleoporin
, gene trap locus 1-13 protein
, gene trap locus-13
, nucleoporin Nup160