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Tumor Necrosis Factor Receptor Superfamily, Member 4 Proteine (TNFRSF4)

Bezeichnung:
Tumor Necrosis Factor Receptor Superfamily, Member 4 Proteine (TNFRSF4)
Auf www.antikoerper-online.de finden Sie aktuell 49 Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) Proteine von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Tumor Necrosis Factor Receptor Superfamily, Member 4 Antikörper (261) und Tumor Necrosis Factor Receptor Superfamily, Member 4 Kits (23) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 343 Tumor Necrosis Factor Receptor Superfamily, Member 4 Produkte verfügbar.
Synonyme:
ACT35, CD134, Ly-70, OX40, TNFRSF4, Txgp1, TXGP1L
alle Proteine anzeigen Gen GeneID UniProt
TNFRSF4 22163 P47741
TNFRSF4 7293 P43489
TNFRSF4 25572 P15725

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Am meisten referenzierte Tumor Necrosis Factor Receptor Superfamily, Member 4 Proteine

  1. Human TNFRSF4 Protein expressed in HEK-293 Cells - ABIN2181573 : Arch, Thompson: 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. in Molecular and cellular biology 1998 (PubMed)
    Zeige alle 2 Referenzen für ABIN2181573

  2. Mouse (Murine) TNFRSF4 Protein expressed in Human Cells - ABIN2008326 : Chen, McAdam, Buhlmann, Scott, Lupher, Greenfield, Baum, Fanslow, Calderhead, Freeman, Sharpe: Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. in Immunity 2000 (PubMed)
    Zeige alle 2 Referenzen für ABIN2008326

  3. Human TNFRSF4 Protein expressed in Human Cells - ABIN2002939 : Calderhead, Buhlmann, van den Eertwegh, Claassen, Noelle, Fell: Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. in Journal of immunology (Baltimore, Md. : 1950) 1993 (PubMed)
    Zeige alle 2 Referenzen für ABIN2002939

Weitere Proteine zu Tumor Necrosis Factor Receptor Superfamily, Member 4 Interaktionspartnern

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) Interaktionspartner

  1. bone marrow-derived mast cell (BMMC)-exosomes facilitated the differentiation of naive CD4 (zeige CD4 Proteine)+ T cells to Th2 cells by ligation of OX40L (zeige TNFSF4 Proteine) and OX40 between BMMC-exosomes and CD4 (zeige CD4 Proteine)+ T cells and represents a novel mechanism of cell-to-cell communication

  2. Crystal structures and NMR data show that the Roquin-1 ROQ domain recognizes hexaloops in the SELEX-derived alternative decay element (ADE) and in an ADE-like variant present in the Ox40 3'-UTR with identical binding modes.

  3. The OX40-OX40 ligand (zeige TNFSF4 Proteine) interaction up-regulates intracellular levels of reactive oxygen species in atherogenesis.

  4. OX40 was highly expressed by intratumoral T cells, particularly those of the FoxP3 (zeige FOXP3 Proteine)(+) regulatory T-cell (Treg) lineage.

  5. OX40 and IL-7 (zeige IL7 Proteine) play synergistic, but distinct roles in the homeostatic proliferation of CD4 (zeige CD4 Proteine)(+) effector memory T cells

  6. OX40-OX40L (zeige TNFSF4 Proteine) interaction regulates the expression of NFATc1 (zeige NFATC1 Proteine), which may play a critical role in atherosclerotic plaque formation, and may therefore have implications with pathophysiology of atherosclerosis.

  7. During CD134 plus CD137 (zeige TNFRSF9 Proteine) dual costimulation, IFN-gamma (zeige IFNG Proteine) interacts with IL-2 (zeige IL2 Proteine) through distinct mechanisms to program maximal expression of effector molecules in antigen-responding T-cells.

  8. OX40 stimulation of virus-specific CD4 (zeige CD4 Proteine) T cells promoted expression of the transcriptional repressor Blimp-1 (zeige PRDM1 Proteine) and diverted the majority of cells away from follicular Th cell differentiation.

  9. interruption of the OX40-OX40L signaling pathway, with decreases in dietary cholesterol, induces regression of atherosclerosis by induction of IL-5-producing T cells and oxidized low-density lipoprotein-specific IgM and reductions in Th2 and mast cells.

  10. OX40-OX40L (zeige TNFSF4 Proteine) interaction promotes proliferation and activation of lymphocytes via NFATc1 (zeige NFATC1 Proteine) in ApoE (zeige APOE Proteine)-deficient mice.

Human Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) Interaktionspartner

  1. this study investigated whether CD134 is preferentially expressed on CD4 (zeige CD4 Proteine) T cells in drug-induced hypersensitivity syndrome .

  2. blocking of both OX-40L (zeige TNFSF4 Proteine) and 4-1BBL (zeige TNFSF9 Proteine) reversed radiation-enhanced T-cell killing of human tumor targets as well as T-cell survival and activation.

  3. Low OX40 expression is associated with colorectal cancer.

  4. OX40 and its ligand are co stimulators for T lymphocytes.

  5. These studies provide the first direct evidence that ligation of tumour necrosis factor (zeige TNF Proteine) superfamily members and their cognate receptors is important for the control of viral lytic replication.

  6. Malaria patients and Plasmodium-infected rodents exhibit enhanced expression of the co-stimulatory receptor OX40 on CD4 (zeige CD4 Proteine) T cells, which is abrogated following coordinate PD-1 (zeige PDCD1 Proteine) co-inhibitory pathways, which are also upregulated during malaria.

  7. Identified two key amino acid residues within CD134 that are required for its interaction with herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells. One of the residues (K79) allows access of the HHV-6B ligand to CD134.

  8. TL1A (zeige TNFSF15 Proteine) increases expression of CD25 (zeige IL2RA Proteine), LFA-1 (zeige ITGAL Proteine), CD134 and CD154 (zeige CD40LG Proteine), and induces IL-22 (zeige IL22 Proteine) and GM-CSF (zeige CSF2 Proteine) production from effector CD4 (zeige CD4 Proteine) T-cells

  9. Data indicate that soluble OX40 and sOX40L plasma levels are increased in early rheumatoid arthritis patients.

  10. High expression of OX40 is associated with type 1 diabetes.

Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.

Alternative names and synonyms associated with Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4)

  • tumor necrosis factor receptor superfamily, member 4 (TNFRSF4)
  • tumor necrosis factor receptor superfamily, member 4 (Tnfrsf4)
  • ACT35 Protein
  • CD134 Protein
  • Ly-70 Protein
  • OX40 Protein
  • TNFRSF4 Protein
  • Txgp1 Protein
  • TXGP1L Protein

Bezeichner auf Proteinebene für TNFRSF4

tumor necrosis factor receptor superfamily, member 4 , tumor necrosis factor receptor superfamily member 4 , OX40 antigen , OX40L receptor , tax-transcriptionally activated glycoprotein 1 , ACT35 antigen , ATC35 antigen , CD134 antigen , OX40 cell surface antigen , OX40 homologue , TAX transcriptionally-activated glycoprotein 1 receptor , lymphoid activation antigene ACT35 , tax-transcriptionally activated glycoprotein 1 receptor , MRC OX40 , Tax-transcriptionally activated glycoprotein 1 , tumor necrosis factor (ligand) superfamily member 4 , tumor necrosis factor superfamily, member 4

GENE ID SPEZIES
457185 Pan troglodytes
489600 Canis lupus familiaris
528782 Bos taurus
699674 Macaca mulatta
22163 Mus musculus
493665 Felis catus
7293 Homo sapiens
25572 Rattus norvegicus
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