anti-Ring Finger Protein 8 (RNF8) Antikörper

Bezeichnung:
anti-Ring Finger Protein 8 Antikörper (RNF8)
Auf www.antikoerper-online.de finden Sie aktuell 101 Ring Finger Protein 8 (RNF8) Antikörper von 18 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Ring Finger Protein 8 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 115 Ring Finger Protein 8 Produkte verfügbar.
Synonyme:
3830404E21Rik, AIP37, fc66f09, hRNF8, RNF8, wu:fc66f09, zgc:55936, zgc:77313

Meistgesuchte Reaktivitäten zu anti-Ring Finger Protein 8 (RNF8) Antikörper

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Am meisten referenzierte anti-Ring Finger Protein 8 Antikörper

  1. Human Polyclonal RNF8 Primary Antibody für EIA, WB - ABIN954577 : Noon, Shibata, Rief, Löbrich, Stewart, Jeggo, Goodarzi: 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. in Nature cell biology 2010 (PubMed)
    Zeige alle 5 Referenzen für 954577

  2. Human Polyclonal RNF8 Primary Antibody für IF, WB - ABIN522468 : Morris, Boutell, Keppler, Densham, Weekes, Alamshah, Butler, Galanty, Pangon, Kiuchi, Ng, Solomon: The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. in Nature 2009 (PubMed)
    Zeige alle 4 Referenzen für 522468

  3. Human Polyclonal RNF8 Primary Antibody für WB - ABIN657354 : Lilley, Chaurushiya, Boutell, Landry, Suh, Panier, Everett, Stewart, Durocher, Weitzman: A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses. in The EMBO journal 2010 (PubMed)
    Zeige alle 3 Referenzen für 657354

  4. Cow (Bovine) Polyclonal RNF8 Primary Antibody für IHC, WB - ABIN2778597 : Lehner, Sanderson: A protein interaction framework for human mRNA degradation. in Genome research 2004 (PubMed)

  5. Human Polyclonal RNF8 Primary Antibody für ELISA, WB - ABIN184931 : Seki, Hattori, Sugano, Suzuki, Nakagawara, Ohhira, Muramatsu, Hori, Saito: Isolation, tissue expression, and chromosomal assignment of a novel human gene which encodes a protein with RING finger motif. in Journal of human genetics 1999 (PubMed)

Weitere Antikörper gegen Ring Finger Protein 8 Interaktionspartner

Mouse (Murine) Ring Finger Protein 8 (RNF8) Interaktionspartner

  1. RNF8-promoted Twist ubiquitination is required for Twist localization to the nucleus for subsequent epithelial-mesenchymal transition and cancer stem cells functions, thereby conferring chemoresistance.

  2. Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.

  3. RNF8(-/-) mice exhibit neuronal degeneration and reactive astrocytosis. Neurons from RNF8(-/-) mice appear to be more susceptible to X-ray-induced DNA damage

  4. Altogether, the data in this study highlight the importance of p53 (zeige TP53 Antikörper)-pathway activation upon loss of Rnf8, suggesting that Rnf8 and p53 (zeige TP53 Antikörper) functionally interact to protect against genomic instability and tumorigenesis.

  5. The identification of RNF8 allows new insights into the integration of the control of p12 (zeige CDK2AP1 Antikörper) degradation by different DNA damage signaling pathways.

  6. RNF8-dependent ubiquitination of histone H2A during meiosis establishes active epigenetic modifications, including dimethylation of H3K4 on the sex chromosomes

  7. A new mechanism of chromatin remodelling-assisted ubiquitylation was shown, which involves cooperation between CHD4 (zeige CHD4 Antikörper) and RNF8 to create a local chromatin environment permissive to the assembly of checkpoint and repair machineries at DNA lesions.

  8. Rnf8 physically interacts with Tpp1 (zeige TPP1 Antikörper) to generate Ubc13 (zeige UBE2N Antikörper)-dependent Lys63 polyubiquitin (zeige UBB Antikörper) chains that stabilize Tpp1 (zeige TPP1 Antikörper) at telomeres.

  9. RNF8 and Chfr (zeige CHFR Antikörper), function together to activate ATM (zeige ATM Antikörper) and maintain genomic stability in vivo.

  10. 53BP1 (zeige TP53BP1 Antikörper) protein binds to Rnf8, suggesting DNA damage involves RNF8 dependent ubiquitylation, which allows its accumulation at damaged chromatin.

Human Ring Finger Protein 8 (RNF8) Interaktionspartner

  1. The study identifies a previously unrecognized role for RNF8 in the negative regulation of NF-kappaB (zeige NFKB1 Antikörper) activation by targeting and deactivating the IKK (zeige CHUK Antikörper) complex.

  2. the role of RNF8-mediated histone H3 (zeige HIST3H3 Antikörper) polyubiquitylation in the regulation of histone H3 (zeige HIST3H3 Antikörper) stability and chromatin modification, is reported.

  3. RNF8- and Ube2S-dependent Lys11-linkage ubiquitin conjugation plays an important role in regulating DNA damage-induced transcriptional silencing, distinct from the role of Lys63-linkage ubiquitin in the recruitment of DNA damage repair proteins 53BP1 and BRCA1.

  4. RNF8-promoted Twist ubiquitination is required for Twist localization to the nucleus for subsequent epithelial-mesenchymal transition and cancer stem cells functions, thereby conferring chemoresistance.

  5. The attenuated DNA damage localization of RNF8 resulting from INT6 (zeige EIF3E Antikörper) depletion could be attributed to the defective retention of ATM (zeige ATM Antikörper).

  6. In late S/G2 (zeige STRN3 Antikörper) phase, the DNA damage-responsive E3 ligase RNF8 conjugates K63-linked ubiquitin chains to tankyrase 1 (zeige TNKS Antikörper), while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1 (zeige FAM175B Antikörper)/BRCC36 (zeige BRCC3 Antikörper)-containing deubiquitinase complex.

  7. Findings indicate direct interaction of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with ring finger protein (C3HC4 type) 8 (RNF8) in regulating response to DNA damage.

  8. High RNF8 expression is associated with bladder cancer.

  9. The interaction of MDC1 (zeige MDC1 Antikörper) with RNF8, but not with ATM (zeige ATM Antikörper) requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 (zeige MDC1 Antikörper) by ATM (zeige ATM Antikörper).

  10. These findings elucidate deeply and extensively the mechanism of RNF8/RNF168 (zeige RNF168 Antikörper) and USP11 (zeige USP11 Antikörper) to maintain the proper status of ubiquitylation gammaH2AX (zeige H2AFX Antikörper) to repair double strand breaks.

Ring Finger Protein 8 (RNF8) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Ring Finger Protein 8 (RNF8)

  • ring finger protein 8 (RNF8) Antikörper
  • ring finger protein 8 (Rnf8) Antikörper
  • ring finger protein 8, E3 ubiquitin protein ligase (RNF8) Antikörper
  • ring finger protein 8, E3 ubiquitin protein ligase (rnf8-a) Antikörper
  • ring finger protein 8, E3 ubiquitin protein ligase (Rnf8) Antikörper
  • ring finger protein 8, E3 ubiquitin protein ligase (rnf8) Antikörper
  • 3830404E21Rik Antikörper
  • AIP37 Antikörper
  • fc66f09 Antikörper
  • hRNF8 Antikörper
  • RNF8 Antikörper
  • wu:fc66f09 Antikörper
  • zgc:55936 Antikörper
  • zgc:77313 Antikörper

Bezeichner auf Proteinebene für RNF8

E3 ubiquitin-protein ligase RNF8 , ActA binding protein 2 , actA-interacting protein 37 , laXp180 , C3HC4-type zinc finger protein , UBC13/UEV-interacting ring finger protein , ring finger protein (C3HC4 type) 8 , E3 ubiquitin-protein ligase RNF8 A , E3 ubiquitin-protein ligase RNF8-A , RING finger protein 8 A , RING finger protein 8-A

GENE ID SPEZIES
515933 Bos taurus
58230 Mus musculus
9025 Homo sapiens
380076 Xenopus laevis
361815 Rattus norvegicus
481775 Canis lupus familiaris
100173982 Pongo abelii
404050 Danio rerio
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