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RNF168, in complex with RAD6A (zeige ube2a ELISA Kits) or RAD6B (zeige UBE2B ELISA Kits), is activated in the DNA-damage-induced protein ubiquitination cascade.
Rnf168 is important for maintaining genomic integrity, and it cooperates with p53 (zeige TP53 ELISA Kits) in suppressing tumorigenesis.
Ubiquitin ligases RNF168, RNF169, and RAD18 (zeige RAD18 ELISA Kits) specifically bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1 (zeige TP53BP1 ELISA Kits) chromatin recruitment may be activated by RNF168 and blocked by RNF169 and RAD18 (zeige RAD18 ELISA Kits).
deregulated RNF168/53BP1 (zeige TP53BP1 ELISA Kits) pathway could promote tumorigenesis by selecting for a more robust, better stress-adapted cancer cell phenotype, through altered DNA repair, fueling genomic instability and tumor heterogeneity
Further mining of the UBE2U interactome uncovered its cognate E3 RNF17 (zeige RNF17 ELISA Kits) as a novel factor that, via the radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties (RIDDLE) syndrome protein RNF168, enforces DNA damage responses.
The association of RNF168 with PML (zeige PML ELISA Kits) NBs (zeige NBN ELISA Kits) resulted in increased ubiquitylation.
Results reveal an important role of USP7 (zeige USP7 ELISA Kits) in regulating ubiquitin-dependent signaling via stabilization of RNF168.
CK2 (zeige CSNK2A1 ELISA Kits)/WIP1 (zeige PPM1D ELISA Kits)-mediated modulation of LSD1 (zeige KDM1A ELISA Kits) phosphorylation facilitates RNF168-dependent ubiquitination and recruitment of 53BP1 (zeige TP53BP1 ELISA Kits) to the DNA damage sites.
The ubiquitin ligase RNF168 is strictly dependent on the activity that UbK27 is required to promote chromatin ubiquitination following DNA damage.
Finding that RNF8 (zeige RNF8 ELISA Kits) is less abundant than RNF168 identifies RNF8 (zeige RNF8 ELISA Kits) as a rate-limiting determinant of focal repair complex assembly
Depletion of RNF8 (zeige RNF8 ELISA Kits) or RNF168 blocks the degradation of diffusely localized nuclear 53BP1 (zeige TP53BP1 ELISA Kits).
The E3 ligase RNF168 promotes both H2A ubiquitylation and neddylation. RNF168 is itself a substrate for NEDD8, and neddylation of RNF168 is necessary for its E3 ubiquitin activity.
This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome.
E3 ubiquitin-protein ligase RNF168
, ring fnger protein 168