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High IKZF1 expression is associated with multiple myeloma.
bioinformatics analysis indicated that both SNPs were located in a putative enhancer area in immune-related cell lines and tissues. A protein-protein interaction analysis found that IKZF1, together with GTF2I (an SS susceptibility gene newly identified through GWAS), could interact with histone deacetylase family proteins. In summary, this is the first study to report an association between IKZF1 and SS in Han Chinese
The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis (zeige CISH Proteine)-element, which engages a THAP11/HCF-1 (zeige HCFC1 Proteine) complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros and NFKB1 (zeige NFKB1 Proteine)
Germline heterozygous IKZF1 mutations cause dysgammaglobulinemia, hematologic abnormalities (including B-cell defects), and autoimmune diseases
Results suggest that the rs1456896 A allele is associated with protective susceptibility to lupus nephritis. However, this association did not seem to be implicated in the disease and histopathological severity of lupus nephritis in the current population, a northern Han Chinese cohort.
elevated Ctnnd1 (zeige CTNND1 Proteine) expression contributes to maintenance of murine B-ALL cells with compromised Ikaros function.
the presence of IKAROS deletion in acute lymphoblastic leukemia in Mexican Mestizos patients could represent a poor-prognosis marker and was probably related to therapy failure
Sumoylated Ikaros is less effective than unsumoylated forms at inhibiting the expansion of murine leukemic cells, and Ikaros sumoylation is abundant in human B-cell acute lymphoblastic leukemic cells, but not in healthy peripheral blood leukocytes. Our results suggest that sumoylation may be important in modulating the tumor suppressor function of Ikaros
our results identify BTG1 as a tumor suppressor in leukemia that, when deleted, strongly enhances the risk of relapse in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia, and augments the glucocorticoid resistance phenotype mediated by the loss of IKZF1 function.
ETV6 (zeige ETV6 Proteine) and IKZF1 are transcriptional regulators not just of ERG (zeige ERG Proteine), but also of a number of genes regulated by a densely interconnected network of seven transcription factors.
These data describe a novel regulatory mechanism through which STAT3 (zeige STAT3 Proteine) and the Ikaros zinc finger transcription factors Aiolos (zeige IKZF3 Proteine) and Ikaros cooperate to regulate Bcl-6 (zeige BCL6 Proteine) expression.
Ikaros is a transcriptional regulator required for maintaining levels of Foxo1 (zeige FOXO1 Proteine) gene expression in naive T-cells.
ADAMTS10 (zeige ADAMTS10 Proteine) is identified as a potential functional integrator of the Ikaros-CtBP (zeige CTBP2 Proteine) chromatin remodeling network.
this study shows that ablation of Ikzf1 in RORgammat+ group 3 innate lymphoid cells results in increased expansion and cytokine production, and protection against infection and colitis
These results indicate that Ikaros is required to limit B1 cell homeostasis in the adult.
These results suggest that Ikaros functions as a negative regulator of follicular B cell activation (zeige BLNK Proteine).
Ikaros functions as a guardian of B-1 lymphoid pattern, and that its absence directs the differentiation of B-1 cells into phagocytes.
Ikaros is a fundamental regulator of PRC2 function in developing T cells.
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).
CLL-associated antigen KW-6
, DNA-binding protein Ikaros
, Ikaros (zinc finger protein)
, ikaros family zinc finger protein 1
, lymphoid transcription factor LyF-1
, zinc finger protein, subfamily 1A, 1 (Ikaros)
, Ikaros transcription factor
, KAROS family zinc finger 1 (Ikaros)
, IKAROS family zinc finger 1 (Ikaros)
, DNA-binding protein Ikaros-like
, zinc finger protein subfamily 1A, 1