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Mouse (Murine) Polyclonal CAD Primary Antibody für ELISA, ICC - ABIN4286809
Hara, Miyake, Arakawa, Kamidono, Hara: Over expression of inhibitor of caspase 3 activated deoxyribonuclease in human renal cell carcinoma cells enhances their resistance to cytotoxic chemotherapy in vivo. in The Journal of urology 2001
Show all 3 Pubmed References
Human Polyclonal CAD Primary Antibody für ICC, IF - ABIN253268
Morin, Fritsch, Mathieu, Gilbert, Guarmit, Firlej, Gallou-Kabani, Vieillefond, Delongchamps, Cabon: Identification of CAD as an androgen receptor interactant and an early marker of prostate tumor recurrence. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
Show all 2 Pubmed References
Using a systematic series of deletion mutants (all containing the intact DNA-binding homeodomain) we discovered that the C-terminal region of Caudal contributes to the preferential activation of the fushi tarazu (ftz (zeige NR5A1 Antikörper)) Caudal target gene.
Bicoid acts through a 63 nt response element in the caudal 3' untranslated region that includes a single miR (zeige MYLIP Antikörper)-2 target site. Four predicted Bicoid splice isoforms are capable of caudal repression; all require the microRNA target for repression.
Abdominal-B and caudal inhibit the formation of specific neuroblasts in the Drosophila tail region.
Bicoid recruits Bin3 to the caudal 3' UTR (zeige UTS2R Antikörper).
Bicoid associates with the 5'-cap-bound complex of caudal mRNA and represses translation.
The caudal homeodomain protein activates Drosophila E2F (zeige E2F2 Antikörper) gene expression.
Transcriptional activation of the Drosophila caudal homeobox (zeige PRRX1 Antikörper) gene by the DRE (zeige SUFUH Antikörper)-binding factor (DREF (zeige ZBED1 Antikörper)).
In this study, we have identified the binding sites for bHLH-PAS (zeige PASK Antikörper) proteins, referred to as CNS midline element (CME), in the 5'-flanking region of the Drosophila caudal gene.
study shows that the intestinal homeobox (zeige PRRX1 Antikörper) gene Caudal regulates the commensal-gut (zeige GUSB Antikörper) mutualism by repressing nuclear factor kappa B-dependent antimicrobial peptide (zeige cAMP Antikörper) genes
Age- and oxidative-stress-related upregulation of the caudal gene is mediated by the NF-kappaB binding site located in the 5'-flanking region of the caudal gene.
CAD functions as a necessary modulator of the hypertrophic response by regulating the mitogen-activated protein kinase (zeige MAPK1 Antikörper)-extracellular signal-regulated kinase 1/2 (zeige MAPK3 Antikörper) signaling pathway in the heart.
the highest order of chromatin compaction observed in the later steps of caspase (zeige CASP3 Antikörper)-dependent apoptosis relies on DFF40/CAD (zeige DFFB Antikörper)-mediated DNA damage by generating 3'-OH ends in single-strand rather than double-strand DNA nicks/breaks
results show that caspase 3 (zeige CASP3 Antikörper)/CAD promotes cell differentiation by directly modifying the DNA/nuclear microenvironment, which enhances the expression of critical regulatory genes
Co-transfection of mouse DFF45 (zeige DFFA Antikörper)(-/-) fibroblasts with plasmids encoding human DFF40 (zeige DFFB Antikörper) and DFF45 (zeige DFFA Antikörper) reversed the apoptosis resistance normally observed in these cells
The thymus of DNase II(-/-)CAD(-/-) embryos contained many foci carrying undigested DNA and the cellularity was severely reduced due to a block in T cell development.
Interactions identified here between mouse liver histone H1 (zeige H1F0 Antikörper) carboxyl-terminal domain and DFF40/CAD (zeige DFFB Antikörper) target and activate linker DNA cleavage during the terminal stages of apoptosis.
The results suggest that CAD protein may be preferentially degraded by the ubiquitin-proteasome system in the absence of its inhibitor (ICAD (zeige DFFA Antikörper)) to maintain protein quality control.
A los of caspase-activated DNASE (zeige DFFB Antikörper) enhances tumorigenesis induced by a chemical carcinogen in a model of skin carcinogenesis in mice.
These findings suggest important posttranslational modifications requiring Cad as an unappreciated mechanism that regulates Notch/Vegf signaling during angiogenesis.
an essential role for CAD in facilitating proliferation and differentiation events in a tissue-specific manner
This study showed that CAD deficiency co-occurrence of anaemia, anisopoikilocytosis, global developmental delay, and seizures.
Changes in glycosylation in caused by mutations in CAD.
These results establish CAD as a downstream effector of Rheb (zeige RHEB Antikörper) and suggest a possible role of Rheb (zeige RHEB Antikörper) in regulating de novo pyrimidine nucleotide synthesis
Recombinant aspartate carbamoyltransferase domain from the CAD enzyme complex forms homotrimers in solution.
The results obtained indicate that mLST8 (zeige MLST8 Antikörper) bridges between CAD and mTOR (zeige FRAP1 Antikörper), and plays a role in the signaling mechanism where CAD is regulated in the mTOR (zeige FRAP1 Antikörper) pathway through the association with mLST8 (zeige MLST8 Antikörper)
preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD
findings show that in prostate tumor cells, CAD fosters androgen receptor (zeige AR Antikörper) translocation into the nucleus and stimulates its transcriptional activity; in radical prostatectomy specimens, CAD expression was not correlated with proliferation markers, but a higher CAD mRNA level was associated with local tumor extension and cancer relapse
the cad gene is regulated by a nonclassical ERalpha (zeige ESR1 Antikörper)/Sp1 (zeige PSG1 Antikörper)-mediated pathway.
Data show that PRMT5 can be found in association with hSWI/SNF complexes and is involved in regulating the expression of carbamoyl-phosphate synthase-aspartate carbamoyltransferase-dihydroorotase.
the nuclear import of CAD appears to promote optimal cell growth
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
, CAD protein
, carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase
, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
, CAD protein-like
, CAD trifunctional protein
, multifunctional protein CAD
, carbamyl phosphatate synthetase 2
, CAD protein carbamylphosphate synthetase domain
, dihydrorotate synthase
, DNA fragmentation factor subunit beta
, DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
, DNA fragmentation factor 40 kDa subunit
, DNA fragmentation factor, 40 kD, beta subunit
, DNase inhibited by DNA fragmentation factor
, caspase-activated DNase
, caspase-activated deoxyribonuclease