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These results suggest that Metnase enhances Exo1 (zeige EXO1 Proteine)-mediated exonuclease (zeige EXO1 Proteine) activity on the lagging strand DNA by facilitating Exo1 (zeige EXO1 Proteine) loading onto a single strand gap at the stalled replication fork.
The SET domain is needed for the 5' end of ss-overhang cleavage with fork and non-fork DNA without affecting the Metnase-DNA interaction. This domain has a positive role in restart of replication fork and the 5' end of ss-overhang cleavage.
methylation of snRNP70 (zeige SNRNP70 Proteine) by SETMAR regulates constitutive and/or alternative splicing
Metnase may possess an important role in DNA repair, topoisomerase II (zeige TOP2 Proteine) function, and the maintenance of stemness during colon cancer development.
293 T transfected with Metnase revealed a large number of rescued plasmids.
found known and novel SETMAR splice variants to be significantly increased in acute myeloid leukemia (zeige BCL11A Proteine)
a single mutation DDN(610) --> DDD (zeige KRT5 Proteine)(610), which restores the ancestral catalytic site, results in loss of function in Metnase
phosphorylation of Metnase S495 differentiates between these two functions, enhancing DSB repair and repressing replication fork restart.
Data show that DBN1 (zeige DBN1 Proteine), SETMAR and HIG2 (zeige HILPDA Proteine) are direct transcriptional targets of the SOX11 (zeige SOX11 Proteine) protein.
DNA repair protein (zeige ATRIP Proteine) Metnase (also SETMAR), which has a SET histone methylase domain, localized to an induced DSB and directly mediated the formation of H3K36me2 near the induced DSB
The suppression of Notch-1 (zeige NOTCH1 Proteine) led to increased expression of Oct4 (zeige POU5F1 Proteine) and Sox2 (zeige SOX2 Proteine), but in decreased gene expression of cMET, Setmar and CD44 (zeige CD44 Proteine).
Metnase may have been selected for because it has a function opposing transposases and may thus play a key role in suppressing translocations that underlie oncogenicity.
This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants.
SET domain and mariner transposase fusion gene
, histone-lysine N-methyltransferase SETMAR
, SET domain and mariner transposase fusion
, SET domain without mariner transposase fusion
, histone-lysine N-methyltransferase SETMAR-like
, SET domain and mariner transposase fusion gene-containing protein
, SET domain and mariner transposase fusion gene-containing protein homolog
, epidermal tumor expressed transcript 2