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anti-TAR DNA Binding Protein (TARDBP) Antikörper

Bezeichnung:
anti-TAR DNA Binding Protein Antikörper (TARDBP)
Auf www.antikoerper-online.de finden Sie aktuell 236 TAR DNA Binding Protein (TARDBP) Antikörper von 25 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TAR DNA Binding Protein Kits (31) und TAR DNA Binding Protein Proteine (14) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 296 TAR DNA Binding Protein Produkte verfügbar.
Synonyme:
1190002A23Rik, ALS10, C85084, DKFZp459I2127, tardbp, TDP-43, Tdp43, wu:fb77f02, wu:fc52g10
Alle Antikörper anzeigen Gen GeneID UniProt
TARDBP 23435 Q13148
TARDBP 230908 Q921F2
TARDBP 298648  

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Meistgesuchte Reaktivitäten zu anti-TAR DNA Binding Protein (TARDBP) Antikörper

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Am meisten referenzierte anti-TAR DNA Binding Protein Antikörper

  1. Chicken Polyclonal TARDBP Primary Antibody für ICC, IF - ABIN188986 : Neumann, Sampathu, Kwong, Truax, Micsenyi, Chou, Bruce, Schuck, Grossman, Clark, McCluskey, Miller, Masliah, Mackenzie, Feldman, Feiden, Kretzschmar, Trojanowski, Lee: Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. in Science (New York, N.Y.) 2006 (PubMed)
    Zeige alle 12 Referenzen für ABIN188986

  2. Human Polyclonal TARDBP Primary Antibody für EIA, IF - ABIN500883 : Buratti, Dörk, Zuccato, Pagani, Romano, Baralle: Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. in The EMBO journal 2001 (PubMed)
    Zeige alle 3 Referenzen für ABIN500883

  3. Human Monoclonal TARDBP Primary Antibody für EIA, IHC (p) - ABIN317572 : Kabashi, Valdmanis, Dion, Spiegelman, McConkey, Vande Velde, Bouchard, Lacomblez, Pochigaeva, Salachas, Pradat, Camu, Meininger, Dupre, Rouleau: TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. in Nature genetics 2008 (PubMed)
    Zeige alle 2 Referenzen für ABIN317572

  4. Cow (Bovine) Polyclonal TARDBP Primary Antibody für IHC, WB - ABIN2780848 : Buratti, Brindisi, Giombi, Tisminetzky, Ayala, Baralle: TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing. in The Journal of biological chemistry 2005 (PubMed)
    Zeige alle 2 Referenzen für ABIN2780848

  5. Cow (Bovine) Polyclonal TARDBP Primary Antibody für IHC, WB - ABIN2780849 : Polymenidou, Lagier-Tourenne, Hutt, Huelga, Moran, Liang, Ling, Sun, Wancewicz, Mazur, Kordasiewicz, Sedaghat, Donohue, Shiue, Bennett, Yeo, Cleveland: Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. in Nature neuroscience 2011 (PubMed)
    Zeige alle 2 Referenzen für ABIN2780849

  6. Human Polyclonal TARDBP Primary Antibody für ELISA, WB - ABIN334503 : Zhang, Xu, Dickey, Buratti, Baralle, Bailey, Pickering-Brown, Dickson, Petrucelli: Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)

  7. Human Polyclonal TARDBP Primary Antibody für IF, WB - ABIN318898 : Ou, Wu, Harrich, García-Martínez, Gaynor: Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. in Journal of virology 1995 (PubMed)

  8. Human Polyclonal TARDBP Primary Antibody für IF, IHC (p) - ABIN657685 : Kim, Shanware, Bowler, Tibbetts: Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. in The Journal of biological chemistry 2010 (PubMed)

Weitere Antikörper gegen TAR DNA Binding Protein Interaktionspartner

Human TAR DNA Binding Protein (TARDBP) Interaktionspartner

  1. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.

  2. Mutant C9ORF72 (zeige C9ORF72 Antikörper) impairs mitochondria activity in a different and opposite manner compared to mutant TDP-43. TARDBP and C9ORF72 (zeige C9ORF72 Antikörper) mutations might trigger cell death by impairing not only RNA metabolism, but also mitochondria activity in ALS (zeige IGFALS Antikörper)/FTD (zeige FTL Antikörper) neurons since their mitochondrial energetic metabolism depends mainly on oxidative phosphorylation.

  3. 14-3-3 eta (zeige YWHAH Antikörper) isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis.

  4. Pathological TAR-DNA binding protein 43 (TDP-43) is cleaved into two major groups of fragments of approximately 35-, approximately 25-kDa, and the truncation at Arg208 completely eliminates the intrinsic ability of RNA recognition motif RRM2 (zeige RRM2 Antikörper) to fold.

  5. TDP-43 dual phosphorylation by MEK, at threonine 153 and tyrosine 155 (p-T153/Y155), was dramatically increased by the heat shock response (HSR) in human cells.

  6. Taken together, inhibition of nuclear import of TDP-43 by cytoplasmic poly-GA inclusions causally links the two main aggregating proteins in C9orf72 (zeige C9ORF72 Antikörper) amyotrophic lateral sclerosis /lobar degeneration pathogenesis.

  7. The aim of this review will be to provide a general overview of TDP-43 and FUS/TLS (zeige FUS Antikörper) proteins and to highlight their physiological functions--{REVIEW}

  8. Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in amyotrophic lateral sclerosis is caused by abnormal autoregulation of TDP-43.

  9. Findings suggest a mechanism in which retrotransposable element (RTE) activity contributes to neurodegeneration in TAR DNA-binding protein 43 (TDP-43)-mediated diseases such as Amyotrophic lateral sclerosis (ALS (zeige IGFALS Antikörper)) and frontotemporal lobar degeneration (FTLD).

  10. Possible role of deregulated DNA binding function of TDP-43 in ALS.

Mouse (Murine) TAR DNA Binding Protein (TARDBP) Interaktionspartner

  1. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.

  2. this study suggests hemizygous TDP-43(M337V) mice as a useful animal model to study TDP-43 toxicity and further consolidates mitochondrial TDP-43 as a novel therapeutic target for TDP-43-linked neurodegenerative diseases.

  3. demonstrated that the levels of HSF1 (zeige HSF1 Antikörper) and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.

  4. The present study identified USP7 (zeige USP7 Antikörper) and TDP-43 as the regulators of CRY1 (zeige CRY1 Antikörper) and CRY2 (zeige CRY2 Antikörper), underscoring the significance of the stability control process of CRY (zeige CRY2 Antikörper) proteins for period determination in the mammalian circadian clockwork.

  5. TDP-43 functions within a network of hnRNP (zeige HNRNPH2 Antikörper) proteins to inhibit the production of a truncated human SORT1 (zeige SORT1 Antikörper) receptor.

  6. Data demonstrate the existence of a physiological decrease of TDP-43/TBPH levels with aging in brain tissue both in wild-type mice and flies, showing that it is an evolutionary conserved phenomenon

  7. This study demonistrated that proprioceptive nerve endings in muscles revealed early and alterations at Ia/II proprioceptive nerve endings in muscle spindles and in the absence of alterations in alpha-motor axons in TDP43(A315T) transgenic mice.

  8. UBQLN2 (zeige UBQLN2 Antikörper) dysregulation in neurons can drive NF-kappaB (zeige NFKB1 Antikörper) activation and cytosolic TDP-43 aggregation.

  9. These findings demonstrate a role for PABPN1 (zeige PABPN1 Antikörper) in rescuing several cytopathological features of TDP-43 proteinopathy by increasing the turnover of pathologic proteins.

  10. identifies DDX58 (zeige DDX58 Antikörper) and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1

Zebrafish TAR DNA Binding Protein (TARDBP) Interaktionspartner

  1. Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein (zeige CNBP Antikörper) tardbp and RNA binding protein fus (zeige FUS Antikörper).

  2. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

  3. TARDBP and FUS (zeige FUS Antikörper) act in a pathogenic pathway that is independent of SOD1 (zeige SOD1 Antikörper).

TAR DNA Binding Protein (TARDBP) Antigen-Profil

Beschreibung des Gens

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Alternative names and synonyms associated with TAR DNA Binding Protein (TARDBP)

  • TAR DNA binding protein (TARDBP) Antikörper
  • Tardbp protein (tardbp) Antikörper
  • TAR DNA binding protein (tardbp) Antikörper
  • TAR DNA binding protein (Tardbp) Antikörper
  • TAR DNA-binding protein 43-like (LOC100621383) Antikörper
  • 1190002A23Rik Antikörper
  • ALS10 Antikörper
  • C85084 Antikörper
  • DKFZp459I2127 Antikörper
  • tardbp Antikörper
  • TDP-43 Antikörper
  • Tdp43 Antikörper
  • wu:fb77f02 Antikörper
  • wu:fc52g10 Antikörper

Bezeichner auf Proteinebene für TARDBP

TAR DNA binding protein , TAR DNA-binding protein 43 , Tardbp protein , TDP-43 , TAR DNA-binding protein-43

GENE ID SPEZIES
100174676 Pongo abelii
457942 Pan troglodytes
713860 Macaca mulatta
778772 Ciona intestinalis
100051482 Equus caballus
100602228 Nomascus leucogenys
380329 Xenopus laevis
419453 Gallus gallus
23435 Homo sapiens
478234 Canis lupus familiaris
540632 Bos taurus
230908 Mus musculus
298648 Rattus norvegicus
325052 Danio rerio
100718595 Cavia porcellus
101114038 Ovis aries
100621383 Sus scrofa
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