Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteine (HIF1A)

Bezeichnung:
Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteine (HIF1A)
Auf www.antikoerper-online.de finden Sie aktuell 50 Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Proteine von 13 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Antikörper (665) und Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Kits (81) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 811 Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Produkte verfügbar.
Synonyme:
AA959795, bHLHe78, hif-1a, HIF-1alpha, HIF1, HIF1-alpha, hif1a, HIF1alpha, MOP1, PASD8
alle Proteine anzeigen Gen GeneID UniProt
HIF1A 15251 Q61221
HIF1A 3091 Q16665
HIF1A 29560 O35800

Weitere Synonyme anzeigen

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Am meisten referenzierte Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteine

  1. Human HIF1A Protein expressed in Escherichia coli (E. coli) - ABIN2004948 : Carbia-Nagashima, Gerez, Perez-Castro, Paez-Pereda, Silberstein, Stalla, Holsboer, Arzt: RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. in Cell 2007 (PubMed)
    Zeige alle 5 Referenzen für 2004948

  2. Human HIF1A Protein expressed in Wheat germ - ABIN1306618 : Vadivel, Alphonse, Etches, van Haaften, Collins, OReilly, Eaton, Thébaud: Hypoxia-inducible factors promote alveolar development and regeneration. in American journal of respiratory cell and molecular biology 2014 (PubMed)
    Zeige alle 3 Referenzen für 1306618

  3. Human HIF1A Protein expressed in Escherichia coli (E. coli) - ABIN667163 : Okuyama, Krishnamachary, Zhou, Nagasawa, Bosch-Marce, Semenza: Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. in The Journal of biological chemistry 2006 (PubMed)

Weitere Proteine zu Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Interaktionspartnern

Mouse (Murine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Interaktionspartner

  1. We conclude that HIF-1 is not a major regulator of Vegfa (zeige VEGFA Proteine) expression during wound healing; rather, it serves to maintain basal levels of expression of Vegfa (zeige VEGFA Proteine) and its target genes in intact skin, which are required for optimal granulation tissue formation in response to wounding.

  2. hypoxic IL-22 (zeige IL22 Proteine) upregulation is dependent on HIF-1alpha

  3. Lactic Acid Suppresses IL-33 (zeige IL33 Proteine)-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1alpha-Dependent miR (zeige MLXIP Proteine)-155 Suppression

  4. Lactic Acid Suppresses IL-33 (zeige IL33 Proteine)-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1alpha-Dependent miR (zeige MLXIP Proteine)-155 Suppression

  5. HIF-1alpha and GDF15 (zeige GDF15 Proteine) expression are inversely related under normoxia and hyperoxia.

  6. HIF-1alpha induced angiogenesis by upregulating not only vascular endothelial growth factor but also miR (zeige MLXIP Proteine)-21 via inhibiting a novel target gene TSP-1 (zeige GZMA Proteine). Both of them may contribute to the protective effect of HIF-1alpha on renal I/R injury.

  7. studies in humans and mice reveal that Akt2 (zeige AKT2 Proteine) controls hepatic tumorigenesis through crosstalk between HNF1alpha (zeige HNF1A Proteine) and PPARgamma (zeige PPARG Proteine).

  8. We conclude that HIF1alpha is activated in alveolar type II cells after lung injury and promotes proliferation and spreading during repair.

  9. HIF1alpha-dependent glycolytic activity is responsible for mTOR (zeige FRAP1 Proteine)-deficient, increased myeloid-derived suppressive cell functional changes in IMH inflammation.

  10. Activation of HIF1A by prolonged in vivo hyperinsulinemia potentiates cancerous progression in estrogen receptor (zeige ESR1 Proteine)-positive breast cancer cells.

Human Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Interaktionspartner

  1. HIF1a is elevated in HUVECs exposed to heme and treatment with hydroxyurea and simvastatin reduced the production.

  2. Results indicated that hypoxia-induced Mxd1 (zeige MXD1 Proteine) expression was mediated by HIF-1alpha in osteosarcoma cells.

  3. HIF-1alpha was destabilised in the presence of bile acids in all tested, human tumor cell lines.

  4. these data suggest that HIF-1alpha expression represents a candidate prognostic biomarker for clinical application in high-grade leiomyosarcoma and undifferentiated pleomorphic sarcoma

  5. HIF-1alpha and GDF15 (zeige GDF15 Proteine) expression are inversely related under normoxia and hyperoxia.

  6. Our findings suggest that GATA3 (zeige GATA3 Proteine) stabilizes HIF-1alpha to enhance cancer invasiveness under hypoxia

  7. Aldolase A promotes lung cancer metastasis via PHD (zeige PDC Proteine)-mediated stabilization of HIF-1alpha and the subsequent activation of MMP9 (zeige MMP9 Proteine).

  8. Findings show that hypoxia inducible factor 1 alpha subunit (HIF-1alpha) is phylogenetically conserved among most metazoans, whereas HIF-2alpha (zeige EPAS1 Proteine) protein appeared later.

  9. present study identifies the crucial regulation of hsa_circ_0010729 on vascular endothelial cell proliferation and apoptosis via targeting miR (zeige MLXIP Proteine)-186/HIF-1alpha axis

  10. TrpC5 (zeige TRPC5 Proteine) induces the epithelial-mesenchymal transition through the HIF-1alpha-Twist signaling pathway to promote tumor metastasis in colon cancer.

Pig (Porcine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Interaktionspartner

  1. a high expression of hypoxia induced factor-1a (HIF-1a) and heat shock protein 70 (HSP70 (zeige HSP70 Proteine)) was noted

  2. Induction of ischemic osteonecrosis results in IL-6 (zeige IL6 Proteine) production in the articular cartilage through an HIF-1-dependent pathway.

  3. Upregulation of VEGF (zeige VEGFA Proteine) during hypoxia in chondrocyte is mediated partially through HIF-1alpha.

  4. HIF-1alpha activates Sox9 (zeige SOX9 Proteine) expression and enhances Sox9 (zeige SOX9 Proteine)-mediated transcriptional activity.

  5. Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.

  6. immunostaining for HIF-1alpha and HIF-2alpha (zeige EPAS1 Proteine) was observed during endochondral ossification, whereas only HIF-2alpha (zeige EPAS1 Proteine) was present at sites of intramembranous ossification

  7. Downregulation of miR (zeige MYLIP Proteine)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 (zeige SIRT1 Proteine) and recapitulates hypoxia preconditioning in cardiac myocytes.

  8. Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF upregulation with subsequent revascularization occurring in the cartilage.

Cow (Bovine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Interaktionspartner

  1. inverse expression and localization pattern of HIF1A and vasohibins during different stages of ovarian function in cow

  2. Hypoxia increased the amounts of HIF1A protein, VEGF mRNA and VEGF protein in cultured bovine luteal cells.

  3. hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity

  4. VEGF has an effect on the expression of its own transcription factor, HIF-1, and on VEGF itself

  5. Identify sphingosine-1-phosphate as a novel and potent nonhypoxic activator of HIF-1.

Rabbit Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Interaktionspartner

  1. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

  2. HIF-1alpha-induced HSP70 (zeige HSP70 Proteine) overexpression increased the expression levels of ECM (zeige MMRN1 Proteine) genes and cell viability, and protected chondrocytes from apoptosis. HIF-1alpha may regulate anabolic effects of chondrocytes under hypoxic conditions by regulating HSP70 (zeige HSP70 Proteine) expression

  3. Transcatheter arterial embolization of liver tumors increases the expression of HIF-1alpha at protein level in the residual viable tumor.

  4. Upregulation of HIF-1 protects cardiac myocyte function after ischemia/reperfusion by maintaining calcium release.

  5. HIF-1alpha expression in early atherosclerosis can promote the formation of neovascularization.

  6. Xells respond to hypoxia through a transcription factor, hypoxia-inducible factor 1

  7. Upregulation of HIF-1 could protect isolated cardiac myocytes against nitrate tolerance through a cyclic GMP protein kinase-independent mechanism and through a kinase-dependent mechanism in myocardial stunning.

  8. rhEPO can down-regulate HIF-1alpha expression in the retina of rabbits with acute high intraocular pressure.

  9. Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion

Caenorhabditis elegans (C. elegans) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Interaktionspartner

  1. blocking HIF-1 activity may promote survival in cells with compromised mitochondrial function.

  2. HIF-1-mediated activation of 5-HT (zeige DDC Proteine) signalling promotes axon regeneration by activating both the RhoA (zeige RHOA Proteine) and cAMP pathways.

  3. this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2 (zeige FMO2 Proteine)).

  4. AMPK (zeige PRKAA1 Proteine) and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS (zeige ROS1 Proteine)

  5. Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.

  6. Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK (zeige PRKAA1 Proteine) compromised C. elegans dauer larvae.

  7. These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.

  8. Data indicate that genes sqrd-1, ethe-1 (zeige ETHE1 Proteine), cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide (zeige SQRDL Proteine) and hydrogen cyanide.

  9. Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner.

  10. Data show that that reactive oxygen species (ROS (zeige ROS1 Proteine)) are increased in respiration mutants and that mild increases in ROS (zeige ROS1 Proteine) can stimulate HIF-1 to activate gene expression and promote longevity.

Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Protein Überblick

Protein Überblick

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Alternative names and synonyms associated with Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A)

  • hypoxia inducible factor 1 alpha (hif-1a)
  • hypoxia inducible factor 1, alpha subunit (Hif1a)
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HIF1A)
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a)
  • hypoxia-inducible factor 1 alpha (hif-1a)
  • hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a)
  • Protein HIF-1 (hif-1)
  • AA959795 Protein
  • bHLHe78 Protein
  • hif-1a Protein
  • HIF-1alpha Protein
  • HIF1 Protein
  • HIF1-alpha Protein
  • hif1a Protein
  • HIF1alpha Protein
  • MOP1 Protein
  • PASD8 Protein

Bezeichner auf Proteinebene für HIF1A

HIF-1 alpha , HIF-1-alpha , HIF1 alpha , HIF1-alpha , Hypoxia-inducible factor 1 alpha , hypoxia-inducible factor 1-alpha , ARNT-interacting protein , ARNT interacting protein , PAS domain-containing protein 8 , basic-helix-loop-helix-PAS protein MOP1 , class E basic helix-loop-helix protein 78 , hypoxia-inducible factor 1 alpha isoform I.3 , hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) , hypoxia-inducible factor1alpha , member of PAS protein 1 , member of PAS superfamily 1 , hypoxia-inducible factor 1 alpha , hypoxia inducible factor 1 alpha subunit , hypoxia inducible factor 1, alpha subunit

GENE ID SPEZIES
100337573 Xenopus laevis
15251 Mus musculus
3091 Homo sapiens
396696 Sus scrofa
281814 Bos taurus
101692645 Mustela putorius furo
443519 Ovis aries
100009579 Oryctolagus cuniculus
480348 Canis lupus familiaris
100713113 Cavia porcellus
374177 Gallus gallus
100135944 Oncorhynchus mykiss
29560 Rattus norvegicus
180359 Caenorhabditis elegans
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