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anti-Human GIPR Antikörper:
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Human Polyclonal GIPR Primary Antibody für IHC (p) - ABIN4314158
Snook, Nelson, Dyck, Wright, Holloway: Glucose-dependent insulinotropic polypeptide directly induces glucose transport in rat skeletal muscle. in American journal of physiology. Regulatory, integrative and comparative physiology 2015
Show all 3 Pubmed References
Human Polyclonal GIPR Primary Antibody für FACS, IHC (p) - ABIN391714
Ugleholdt, Pedersen, Bassi, Füchtbauer, Jørgensen, Kissow, Nytofte, Poulsen, Rosenkilde, Seino, Thams, Holst, Holst: Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain. in The Journal of biological chemistry 2011
Cow (Bovine) Polyclonal GIPR Primary Antibody für IHC (p) - ABIN4314159
Figueiredo, Antunes, Moreira, de Mello, Medeiros, Di Giunta, Lobão-Soares, Linhares, Lin, Mazzuco, Prediger, Walz: Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus. in Peptides 2011
Human Polyclonal GIPR Primary Antibody für IHC (p) - ABIN270972
Prasadan, Koizumi, Tulachan, Shiota, Lath, Paredes, Guo, El-Gohary, Malek, Shah, Gittes: The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreas. in Diabetes 2011
Data suggest that GIPR (gastric inhibitory polypeptide receptor) is among the few GPCRs (G-protein-coupled receptors) which signal through G-proteins (GTP-binding protein Gs alpha subunit (zeige GNAS Antikörper), here) both at plasma membrane and in endosomes; recombinant proteins expressed in HEK293 cells were used in these studies.
GIPR overexpression does not appear to affect acromegalic patients' clinical features
Study shows the internalization of GIPR involving clathrin-coated pits, AP-2 (zeige GTF3A Antikörper) and dynamin (zeige DNM1 Antikörper) and its subsequent intracellular trafficking. GIP (zeige GIP Antikörper) stimulates a rapid robust internalization of the GIPR, the major part being directed to lysosomes.
The common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes.
Body mass index change for the A/T+A/A in GIPR genotypes was significantly higher than that for the T/T genotype. rs10423928 may predict weight gain in schizophrenia.
The potential future role of gastric inhibitory peptide (GIP (zeige GIP Antikörper)) receptors as molecular targets in neuroendocrine neoplasms may be dependent on the tumor grade.
Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP (zeige GIP Antikörper)-stimulated and unstimulated adipocytes.
GIPR is overexpressed in gastric and duodenal neuroendocrine tumors
GIPR expression was downregulated in subcutaneous adipose tissue from obese patients and correlated negatively with body mass index, waist circumference, systolic blood pressure, and glucose and triglyceride levels.
GIPR promoter was hypomethylated in type 2 diabetic patients as compared to controls.
Microarray analysis revealed that pregnancy-specific glycoprotein 17 (Psg17), a potential CD9 (zeige CD9 Antikörper)-binding partner, was significantly decreased in GIP (zeige GIP Antikörper) receptor-knockout (Gipr-/-) testes.
GIPR signaling in adipose tissue plays a critical role in high fat diet-induced insulin (zeige INS Antikörper) resistance and hepatic steatosis in vivo, which may involve IL-6 (zeige IL6 Antikörper) signaling.
Genetic deletion of both GLP-1 (zeige GCG Antikörper) and GIP (zeige GIP Antikörper) receptors reveals that they are required to maintain an adequate islet number in adulthood and to maintain normal beta cell responses to glucose.
Results suggest the beneficial effects of glucose-dependent insulinotropic polypeptide (zeige GIP Antikörper) on periodontal disease.
Gipr(-/-) offspring of mice exposed to high fat diet(HFD) during pregnancy/lactation became insulin (zeige INS Antikörper) resistant and obese and exhibited increased adipose tissue inflammation and decreased peripheral tissue substrate utilization after reintroduction of HFD.
Beta-cell Gipr KO mice exhibit lower levels of meal-stimulated insulin (zeige INS Antikörper) secretion, decreased expansion of adipose tissue mass and preservation of insulin (zeige INS Antikörper) sensitivity and decreased TCF1 (zeige HNF1A Antikörper) expression.
Gipr is expressed in healthy arteries, predominantly in endothelial cells.
These data highlighted the importance of intact GIPR signalling and dietary composition in modulating memory and learning, and hippocampal pathways involved in the maintenance of synaptic plasticity
Functional GIP (zeige GIP Antikörper) receptors play a major role in islet compensatory response to high fat feeding in mice.
our data demonstrate that the expression of GLP-1R (zeige GLP1R Antikörper) and GIPR is regulated by glucose (zeige ZNF236 Antikörper) concentrations in MC3T3-E1 cells undergoing differentiation induced by BMP-2 (zeige BMP2 Antikörper).
Data suggest that high levels of blood glucose or AGEs (advanced glycation end products), as seen in hyperglycemia, reduce secretion of insulin (zeige INS Antikörper) by pancreatic beta cells via antagonism of GIP (gastric inhibitory polypeptide (zeige GIP Antikörper))/GIP (zeige GIP Antikörper) receptor signaling.
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
gastric inhibitory polypeptide receptor
, glucagon receptor
, gastric inhibitory polypeptide receptor-like
, glucose-dependent insulinotropic polypeptide receptor
, gastric inhibitory peptide receptor