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Dapper1 attenuates hepatic gluconeogenesis and lipogenesis in Ttype 2 diabetes.
Dpr1 promotes the ubiquitination of Dvl2 (zeige DVL2 Proteine) by pVHL (zeige VHL Proteine) and mediates the protein aggregate-elicited autophagy initiation
Expression analysis of Dact1-LacZ (zeige GLB1 Proteine) show high expression levels in multiple mesoderm- and neuroectoderm-derived tissues during embryonic development, but restricted to a small number of postnatal tissues.
These results support a novel cell-autonomous postsynaptic role for Dact1, in cooperation with Dishevelled-1 (zeige DVL1 Proteine) and possibly Disrupted in Schizophrenia-1 (zeige DISC1 Proteine), in the formation of synapses on cortical interneuron dendrites.
Depletion of Dapper-1 and dishevelled-2 (zeige DVL2 Proteine) in cardiomyocytes demonstrated that Dapper-1 functions upstream of dishevelled-2 (zeige DVL2 Proteine) and that activity of both Dapper-1 and dishevelled-2 (zeige DVL2 Proteine) is essential for activating canonical Wnt (zeige WNT2 Proteine) signaling.
conserved role for Dact1 protein in kinase-regulated biochemistry involving Vangl and Dvl (zeige DVL1 Proteine).
Dact1 was upregulated in the dental follicle mesenchyme at the cap stage and subsequently also in the dental papilla at the bell stage, where the expression persisted to the postnatal stages.
Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled (zeige DVL2 Proteine) activity and leads to posterior malformation in mice.
This study shown that Dact1 plays an important role during dendrite and spine formation in neurons of the mammalian forebrain by promoting activation of Rac (zeige AKT1 Proteine)
Frodo is expressed in primitive streak mesoderm, neuroectoderm, neural crest, presomitic mesoderm, and somites. In many cases, Frodo expression is confined to tissues undergoing extensive morphogenesis
frd1 is expressed in the developing brain and mesoderm.
two Dvl (zeige DVL2 Proteine)-associated paralogs, Dpr1 and Dpr2 (zeige DACT2 Proteine), participate in distinct Wnt (zeige WNT2 Proteine)-dependent developmental processes
target of beta-catenin (zeige CTNNB1 Proteine) and/or an unknown downstream effector in development
An inhibitory role for DACT1 in leukemogenesis.
Dact1 is up-regulated by TGF-beta1 (zeige TGFB1 Proteine), inducing apoptosis in mesangial cells.
The simultaneous methylation of DACT1 and DACT2 (zeige DACT2 Proteine) may play important roles in progression of ESCC and may serve as prognostic methylation biomarkers for ESCC patients.
Dact1 has a critical role in the ability support keratinocyte proliferation, by attenuating Wnt (zeige WNT2 Proteine)/beta catenin (zeige CTNNB1 Proteine) signaling.
our results suggested that DACT1 was upregulated during human placenta development.
There was no statistical difference between groups concerning DACT1 and DACT2 (zeige DACT2 Proteine) either in promoter hypermethylation or transcript levels. Age was associated with DACT2 (zeige DACT2 Proteine) promoter hypermethylation, especially over 56 years old.
Overexpression of Dapper-1 allows the translocation of MIZ-1 (zeige ZBTB17 Proteine) from the nucleus to the cytoplasm.
Dpr1 directly interacts with Beclin1 (zeige BECN1 Proteine) and Atg14L and enhances the Beclin1 (zeige BECN1 Proteine)-Vps34 (zeige PIK3C3 Proteine) interaction and Vps34 (zeige PIK3C3 Proteine) activity.
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene.
dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
, dapper 1
, dapper, antagonist of beta-catenin
, dapper, antagonist of beta-catenin, homolog 1
, dapper homolog 1-like
, dapper antagonist of catenin 1
, dapper homolog 1
, frodo homolog
, thymus expressed gene 3
, thymus-expressed novel gene 3 protein
, dishevelled-interacting protein
, frodo 1
, hepatocellular carcinoma novel gene 3 protein
, heptacellular carcinoma novel gene 3
, dapper 1-B
, dapper homolog 1, antagonist of beta-catenin