DACT1 Proteine (DACT1)

Bezeichnung:
Dapper, Antagonist of beta-Catenin, Homolog 1 (Xenopus Laevis) Proteine (DACT1)
Auf www.antikoerper-online.de finden Sie aktuell 3 Dapper, Antagonist of beta-Catenin, Homolog 1 (Xenopus Laevis) (DACT1) Proteine von 2 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen DACT1 Antikörper (40) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 45 DACT1 Produkte verfügbar.
Synonyme:
4921528D17Rik, AI115603, dact1, DAPPER, DAPPER1, dpr, DPR1, frd1, FRODO, frodo1, HDPR1, MDpr1, MGC89695, MTNG3, RGD1564008, THYEX3, XDpr, XDpr1a
alle Proteine anzeigen Gen GeneID UniProt
DACT1 59036 Q8R4A3
DACT1 51339 Q9NYF0
Ratte DACT1 DACT1 500666  

Weitere Synonyme anzeigen

DACT1 Proteine (DACT1) nach Spezies

Wählen Sie die gewünschte Spezies

Weitere Proteine zu DACT1 Interaktionspartnern

Mouse (Murine) Dapper, Antagonist of beta-Catenin, Homolog 1 (Xenopus Laevis) (DACT1) Interaktionspartner

  1. Dpr1 promotes the ubiquitination of Dvl2 (zeige DVL2 Proteine) by pVHL (zeige VHL Proteine) and mediates the protein aggregate-elicited autophagy initiation

  2. Expression analysis of Dact1-LacZ (zeige GLB1 Proteine) show high expression levels in multiple mesoderm- and neuroectoderm-derived tissues during embryonic development, but restricted to a small number of postnatal tissues.

  3. These results support a novel cell-autonomous postsynaptic role for Dact1, in cooperation with Dishevelled-1 (zeige DVL1 Proteine) and possibly Disrupted in Schizophrenia-1 (zeige DISC1 Proteine), in the formation of synapses on cortical interneuron dendrites.

  4. Depletion of Dapper-1 and dishevelled-2 (zeige DVL2 Proteine) in cardiomyocytes demonstrated that Dapper-1 functions upstream of dishevelled-2 (zeige DVL2 Proteine) and that activity of both Dapper-1 and dishevelled-2 (zeige DVL2 Proteine) is essential for activating canonical Wnt (zeige WNT2 Proteine) signaling.

  5. conserved role for Dact1 protein in kinase-regulated biochemistry involving Vangl and Dvl (zeige DVL1 Proteine).

  6. Dact1 was upregulated in the dental follicle mesenchyme at the cap stage and subsequently also in the dental papilla at the bell stage, where the expression persisted to the postnatal stages.

  7. Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled (zeige DVL2 Proteine) activity and leads to posterior malformation in mice.

  8. This study shown that Dact1 plays an important role during dendrite and spine formation in neurons of the mammalian forebrain by promoting activation of Rac (zeige AKT1 Proteine)

  9. Frodo is expressed in primitive streak mesoderm, neuroectoderm, neural crest, presomitic mesoderm, and somites. In many cases, Frodo expression is confined to tissues undergoing extensive morphogenesis

  10. Dact1 is detected in the presomitic mesoderm and somites during segmentation, in the limb bud mesenchyme and other mesoderm-derived tissues, and in the central nervous system

Zebrafish Dapper, Antagonist of beta-Catenin, Homolog 1 (Xenopus Laevis) (DACT1) Interaktionspartner

  1. frd1 is expressed in the developing brain and mesoderm.

  2. two Dvl (zeige DVL2 Proteine)-associated paralogs, Dpr1 and Dpr2 (zeige DACT2 Proteine), participate in distinct Wnt (zeige WNT2 Proteine)-dependent developmental processes

  3. target of beta-catenin (zeige CTNNB1 Proteine) and/or an unknown downstream effector in development

Human Dapper, Antagonist of beta-Catenin, Homolog 1 (Xenopus Laevis) (DACT1) Interaktionspartner

  1. Dact1 is up-regulated by TGF-beta1 (zeige TGFB1 Proteine), inducing apoptosis in mesangial cells.

  2. The simultaneous methylation of DACT1 and DACT2 (zeige DACT2 Proteine) may play important roles in progression of ESCC and may serve as prognostic methylation biomarkers for ESCC patients.

  3. Dact1 has a critical role in the ability support keratinocyte proliferation, by attenuating Wnt (zeige WNT2 Proteine)/beta catenin (zeige CTNNB1 Proteine) signaling.

  4. our results suggested that DACT1 was upregulated during human placenta development.

  5. There was no statistical difference between groups concerning DACT1 and DACT2 (zeige DACT2 Proteine) either in promoter hypermethylation or transcript levels. Age was associated with DACT2 (zeige DACT2 Proteine) promoter hypermethylation, especially over 56 years old.

  6. Dpr1 promotes the ubiquitination of Dvl2 (zeige DVL2 Proteine) by pVHL (zeige VHL Proteine) and mediates the protein aggregate-elicited autophagy initiation

  7. Overexpression of Dapper-1 allows the translocation of MIZ-1 (zeige ZBTB17 Proteine) from the nucleus to the cytoplasm.

  8. Dpr1 directly interacts with Beclin1 (zeige BECN1 Proteine) and Atg14L and enhances the Beclin1 (zeige BECN1 Proteine)-Vps34 (zeige PIK3C3 Proteine) interaction and Vps34 (zeige PIK3C3 Proteine) activity.

  9. Data indicate that Sestd1 (zeige SESTD1 Proteine) cooperates with Dact1 in Vangl2 (zeige VANGL2 Proteine) regulation and in the planar cell polarity (PCP (zeige PRCP Proteine)) pathway during mammalian embryonic development.

  10. five missense heterozygote mutations of the DACT1 gene are specifically identified in 167 stillborn or miscarried Han Chinese fetuses with neural tube defects.

DACT1 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with DACT1

  • dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) (DACT1)
  • dapper, antagonist of beta-catenin (dact1)
  • dishevelled-binding antagonist of beta-catenin 1 (DACT1)
  • dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) (dact1)
  • dapper homolog 1, antagonist of beta-catenin (xenopus) (Dact1)
  • dapper homolog 1, antagonist of beta-catenin (xenopus) (dact1)
  • dishevelled-binding antagonist of beta-catenin 1 (dact1-b)
  • dishevelled-binding antagonist of beta-catenin 1 (Dact1)
  • 4921528D17Rik Protein
  • AI115603 Protein
  • dact1 Protein
  • DAPPER Protein
  • DAPPER1 Protein
  • dpr Protein
  • DPR1 Protein
  • frd1 Protein
  • FRODO Protein
  • frodo1 Protein
  • HDPR1 Protein
  • MDpr1 Protein
  • MGC89695 Protein
  • MTNG3 Protein
  • RGD1564008 Protein
  • THYEX3 Protein
  • XDpr Protein
  • XDpr1a Protein

Bezeichner auf Proteinebene für DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) , dapper 1 , dapper, antagonist of beta-catenin , dapper, antagonist of beta-catenin, homolog 1 , dapper homolog 1-like , dapper antagonist of catenin 1 , dapper homolog 1 , frodo homolog , thymus expressed gene 3 , thymus-expressed novel gene 3 protein , dishevelled-interacting protein , frodo 1 , hepatocellular carcinoma novel gene 3 protein , heptacellular carcinoma novel gene 3 , dapper 1-B , dapper1a , xDpr , dapper homolog 1, antagonist of beta-catenin

GENE ID SPEZIES
452938 Pan troglodytes
493325 Xenopus (Silurana) tropicalis
538778 Bos taurus
701218 Macaca mulatta
100021268 Monodelphis domestica
100339172 Oryctolagus cuniculus
100400795 Callithrix jacchus
100437942 Pongo abelii
100546955 Meleagris gallopavo
100555885 Anolis carolinensis
100606126 Nomascus leucogenys
59036 Mus musculus
405799 Danio rerio
723789 Gallus gallus
100687551 Canis lupus familiaris
51339 Homo sapiens
399186 Xenopus laevis
500666 Rattus norvegicus
Ausgewählte Anbieter für DACT1 Proteine (DACT1)
Haben Sie etwas anderes gesucht?