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XSENP1a and XSENP1b are sumo-specific proteases that inhibit normal head formation by inhibiting Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling.
Molecular dynamics simulations showed that binding of the beta-grasp domain of SUMO1 (zeige SUMO1 ELISA Kits) induces significant conformational and dynamic changes in SENP1, including widening of the exosite cleft and quenching of nanosecond dynamics in all but a distal region.
GATA1 (zeige GATA1 ELISA Kits) is an essential downstream target of SENP1 and that the differential expression and response of GATA1 (zeige GATA1 ELISA Kits) and Bcl-xL (zeige BCL2L1 ELISA Kits) are a key mechanism underlying chronic mountain sickness pathology.
miRNA1236 regulates hypoxia-induced epithelial-mesenchymal transformation and metastasis by repressing HDAC3 (zeige HDAC3 ELISA Kits) and SENP1 expression.
SENP1 deSUMOylated SMAD4 (zeige SMAD4 ELISA Kits) to promote EMT (zeige ITK ELISA Kits) via up-regulating E-cadherin (zeige CDH1 ELISA Kits) in prostate cancer cells. Therefore, SENP1 is a potential target for treatment of advanced prostate cancer.
The variability of the SENP1 and SENP2 genes may play a role in breast cancer occurrence.
this study elucidated that SENP1 is essential for triple-negative breast cancer cell proliferation and migration in vitro, as well as tumor formation and metastasis in vivo
Hepatocellular carcinoma cells express a high level of Senp1 which is induced by HGF/c-Met signals. Senp1 silencing reduces the HGF (zeige HGF ELISA Kits)-induced proliferation and migration of HCC (zeige FAM126A ELISA Kits) cells, induces HCC (zeige FAM126A ELISA Kits) cell apoptosis and growth arrest, and epithelial-to-mesenchymal transition, with increase of E-cadherin (zeige CDH1 ELISA Kits) and ZO-1 (zeige TJP1 ELISA Kits) expression, decrease of fibronectin (zeige FN1 ELISA Kits) and N-cadherin (zeige CDH2 ELISA Kits) expression.
a significant role of SENP1 in the regulation of cell migration and invasion in neuroblastoma (zeige ARHGEF16 ELISA Kits)
A key role for SENP1 in astrocytoma development and apoptosis.SENP1 inhibition promotes cell apoptosis by regulating NF-kappa B (zeige NFKB1 ELISA Kits)/Akt (zeige AKT1 ELISA Kits) signaling pathways.
Genetic interactions of SNPs in CARD14 (zeige CARD14 ELISA Kits), SENP1 and VEGFA (zeige VEGFA ELISA Kits) might represent a functional mechanism in the pathogenesis of high altitude polycythemia.
knockdown of SENP1 augments the ability of Shh (zeige SHH ELISA Kits) to sustain the proliferation of cerebellar granule cell precursors, demonstrating the physiological significance of the negative regulation of Shh (zeige SHH ELISA Kits) signaling by SENP1.
SUMO1 (zeige SUMO1 ELISA Kits) conjugation of RB and Lamin A/C (zeige LMNA ELISA Kits) is modulated by the SUMO protease SENP1 and that sumoylation of both proteins is required for their interaction.
SENP1 plays a neuroprotective role in ischemia/reperfusion injury.
a novel negative feedback loop mediated by STAT3 (zeige STAT3 ELISA Kits)-SOCS3 (zeige SOCS3 ELISA Kits), which is tightly controlled by SENP1 via de-SUMOylation of protein tyrosine phosphatase 1B (PTP1B (zeige PTPN1 ELISA Kits)), in IFN-gamma (zeige IFNG ELISA Kits) signaling, is reported.
SENP1 deletion in adipocytes causes Type 1 diabetes mellitus via enhanced SUMOylation of NEMO (zeige IKBKG ELISA Kits), leading to increased NF-kappaB (zeige NFKB1 ELISA Kits) activity, cytokine production and pancreatic inflammation.
results of the present study are of both theoretical and therapeutic significance to explore the potential roles of SENP1 under IH condition and elucidated the mechanisms underlying microglial survival and activation
A role for islet SENP1 as a regulator of in vivo glucose homeostasis was demonstrated by the tissue-selective and inducible knockout of this enzyme.
SENP1 up-regulation in diseased heart is mediated via calcineurin-NFAT (zeige NFATC1 ELISA Kits)/MEF2C (zeige MEF2C ELISA Kits)-PGC-1alpha (zeige PPARGC1A ELISA Kits) pathway.
SENP1 deficiency exacerbates ischemia-reperfusion injury in cardiomyocytes via a HIF1alpha (zeige HIF1A ELISA Kits)-dependent pathway.
SENP1 enhances adipogenesis through de-SUMOylation of Sharp-1 (zeige BHLHE41 ELISA Kits), which then releases Sharp-1 (zeige BHLHE41 ELISA Kits) repression of PPARgamma (zeige PPARG ELISA Kits) expression and adipocyte differentiation. These results reveal SENP1 as a novel regulator in adipogenesis.
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants.
sentrin-specific protease 1
, SUMO1/sentrin specific peptidase 1
, sentrin/SUMO-specific protease 1
, similar to Sentrin-specific protease 1 (Sentrin/SUMO-specific protease SENP1)
, sentrin/SUMO-specific protease SENP1
, sentrin specific protease 1b
, SUMO1/sentrin specific protease 1
, SUMO-1 protease 2
, SUMO-specific protease U1p1
, sentrin specific protease 1a
, Sumo1/sentrin/SMT3 specific peptidase 1