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These results suggest that a change in the intracellular calcium level plays a role in regulation of the secretory pathway via interaction of ALG-2 with MISSL and MAP1B (zeige MAP1B ELISA Kits).
The gene copy numbers and mRNA levels for both ALG-2 and HEBP2 are significantly upregulated in breast and lung cancer. Coexpression of ALG-2 and HEBP2 markedly increases the cytoplasmic pool of ALG-2 and alters the subcellular distribution of HEBP2. Abnormalities in the ALG-2/HEBP2 interaction impairs spindle orientation and positioning during mitosis.
The results suggest that ALG-2 acts as a Ca2 (zeige CA2 ELISA Kits)+-sensitive adaptor to concentrate and polymerize TFG at endoplasmic reticulum exit sites, supporting a potential role for ALG-2 in COPII-dependent trafficking from the endoplasmic reticulum.
ALG2 has a tumor suppressive role in glioblastoma and might be a potential target for the treatment of glioblastoma.
miR (zeige MLXIP ELISA Kits)-183 may function as an oncogene (zeige RAB1A ELISA Kits) and may enhance cell proliferation by targeting PDCD6, implying a potential therapeutic target for this malignancy.
Our results suggest that PDCD6 may play an important role in the pathogenesis of cervical squamous cell carcinoma
PDCD6 may represent a biomarker candidate gene that could help to identify a group of patients at high risk for recurrence and death.
Palmitoylation sites and the N-terminal Pro-rich region were necessary for efficient secretion, but ABSs (ALG-2-binding sites) were dispensable.
The present study provided evidence that rs4957014 and rs3756712 are associated with Uterine leiomyoma (UL) risk, the results indicated that genetic polymorphisms in PDCD6 may contribute to the development of UL.
CHERP and ALG-2 participate in regulation of alternative splicing of IP3R1 (zeige ITPR1 ELISA Kits) pre-mRNA and provide new insights into post-transcriptional regulation of splicing variants in Ca(2 (zeige CA2 ELISA Kits)+) signaling pathways.
ALG2 regulates glioblastoma cell proliferation, migration and tumorigenicity.
Substitution of either L52 with Ala or F148 with Ser (zeige SIGLEC1 ELISA Kits) of ALG-2 caused loss of binding abilities to PLSCR3 (zeige PLSCR3 ELISA Kits) lacking type 1 motif but retained those to PLSCR3 (zeige PLSCR3 ELISA Kits) lacking type 2 motif
ALG-2 is physiologically dispensable for apoptotic responses (ALG-2 protein)
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5.
programmed cell death 6
, programmed cell death protein 6
, apoptosis-linked gene 2 protein
, probable calcium-binding protein ALG-2