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p54 (zeige DDX6 ELISA Kits)-S6K2 interactome is predominant to the nucleus, whereas p70-S6K1 (zeige RPS6KB1 ELISA Kits) is predominant to cytosol.
Overexpression of catalytically-active Akt (zeige AKT1 ELISA Kits) or knockdown of glycogen synthase kinase-3 (GSK3)-beta (zeige GSK3b ELISA Kits), a substrate for Akt (zeige AKT1 ELISA Kits), had little effect on Mcl-1 (zeige MCL1 ELISA Kits) downregulation caused by S6K2 deficiency
We propose that the S6K2/TRBP (zeige TARBP2 ELISA Kits) node controls miRNA biogenesis in HDLECs and provides a molecular link between the mTOR (zeige FRAP1 ELISA Kits) pathway and the miRNA biogenesis machinery.
discovered that ERBB4 (zeige ERBB4 ELISA Kits) and S6K2 were the direct targets of miR (zeige MLXIP ELISA Kits)-193a-3p and that PIK3R3 and mTOR (zeige FRAP1 ELISA Kits) were the direct targets of miR (zeige MLXIP ELISA Kits)-193a-5p in non-small-cell lung cancer
Degradation of Tiam1 by casein kinase 1 (zeige CSNK1A1 ELISA Kits) and the SCFbetaTrCP ubiquitin ligase controls the duration of mTOR (zeige FRAP1 ELISA Kits)-S6K (zeige RPS6KB1 ELISA Kits) signaling.
The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer.
The p85 S6K1 (zeige RPS6KB1 ELISA Kits) promotes H2O2-induced cell death via a rapamycin-insensitive mechanism.
S6K2 amplification was frequently observed in gastric cancer and was related to a poor prognosis
S6K1 and S6K2 gene amplification was associated with a worse prognosis.
S6K2 expression dictates tissue-specific requirement for S6K1 (zeige RPS6KB1 ELISA Kits) in mediating aberrant mTORC1 signaling and tumorigenesis
S6K2 loss reduces Th17 skewing and increases regulatory T cell differentiation.
the p70S6K (zeige RPS6KB1 ELISA Kits) isoforms have unique and redundant functions in mediating fibrogenic processes, including proliferation, migration.
S6K2 regulates hepatic energy homeostasis by repressing PPARalpha (zeige PPARA ELISA Kits) activity.
metabolic functions of S6K (zeige RPS6KB1 ELISA Kits) in vivo play a key role as a molecular interface connecting dietary lipids to the endogenous control of energy metabolism.
Data show that the absence of ribosomal protein S6 (zeige RPS6 ELISA Kits) kinases 1 and 2 (S6K1 (zeige RPS6KB1 ELISA Kits) and S6K2) profoundly impairs animal viability but does not seem to affect the proliferative responses of cells derived from the distinct S6K (zeige RPS6KB1 ELISA Kits) genotypes.
S6K2 is activated by IL-3 (zeige IL-3 ELISA Kits) in the IL-3 (zeige IL-3 ELISA Kits)-dependent Ba/F3 cell line and this is mediated by mTOR (zeige FRAP1 ELISA Kits) and its upstream activator PI-3K but not by MAPK (zeige MAPK1 ELISA Kits) signal pathways.
parallel increase in p70S6K (zeige RPS6KB1 ELISA Kits) activation and tau phosphorylation could be demonstrated by treating wild-type N2a cells with Abeta25-35
mGluR (zeige GRM8 ELISA Kits)-LTD is associated with PI3K-, mTOR (zeige FRAP1 ELISA Kits)-, and ERK (zeige EPHB2 ELISA Kits)-dependent alterations in the phosphorylation of S6 and S6K (zeige RPS6KB1 ELISA Kits).
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
70 kDa ribosomal protein S6 kinase 2
, S6 kinase-related kinase
, p70 S6 kinase beta
, p70 S6K-beta
, p70 S6KB
, p70 ribosomal S6 kinase beta
, p70-S6K 2
, ribosomal protein S6 kinase beta-2
, serine/threonine-protein kinase 14 beta
, serine/threonine-protein kinase 14B
, ribosomal protein S6 kinase, 70kDa, polypeptide 2
, S6 kinase 2
, ribosomal protein S6 kinase, 70kD, polypeptide 2