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FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner.
These data suggest that S6K1 (zeige RPS6KB1 ELISA Kits)-mediated PIPKIgamma90 phosphorylation regulates cell migration and invasion by controlling PIPKIgamma90 degradation.
PIPKIgammai5, NEDD4-1 (zeige NEDD4 ELISA Kits), and Mig6 (zeige ERRFI1 ELISA Kits) form a novel molecular nexus that controls EGFR (zeige EGFR ELISA Kits) activation and downstream signaling.
PIPKIgamma and INPP5E (zeige PMPCA ELISA Kits) localize to the centrosome and coordinate the initiation of ciliogenesis.
results suggested that Akt (zeige AKT1 ELISA Kits)-mediated PIP5Kgamma90 S555 phosphorylation is a novel regulatory point for talin binding to control PIP2 level at the FAs (zeige FAS ELISA Kits), thereby modulating FA dynamics and cell motility.
Loss of PIPKIgamma or its focal adhesion-targeting variant, PIPKIgammai2, impaired PI3K (zeige PIK3CA ELISA Kits)/Akt (zeige AKT1 ELISA Kits) activation upon stimulation with growth factors or extracellular matrix proteins in different tumor cells.
PIPKIgamma binds to the cryptic polo (zeige PLK1 ELISA Kits)-box domain of PLK4 (zeige PLK4 ELISA Kits) and reduces the kinase activity of PLK4 (zeige PLK4 ELISA Kits).
This study uncovers a novel mechanism where a phosphoinositide-synthesizing enzyme, PIPKIgammai2, functions with the proto-oncogene (zeige RAB1A ELISA Kits) Src (zeige SRC ELISA Kits), to regulate oncogenic signaling
PIPKIgamma and phosphatidyl inositol phosphate pools at nascent E-cadherin (zeige CDH1 ELISA Kits) contacts cue Exo70 (zeige EXOC7 ELISA Kits) targeting and orient the tethering of exocyst-associated E-cadherin (zeige CDH1 ELISA Kits)
PIPKIgamma positively regulates focal adhesion dynamics and cancer invasion, most probably through PIP (zeige PIP ELISA Kits)-mediated vinculin (zeige VCL ELISA Kits) activation.
Pip5k1a activity is regulated by dimerization and binding with the DIX domain of dishevelled (zeige DVL2 ELISA Kits).
PIPKIgamma and INPP5E (zeige INPP5E ELISA Kits) localize to the centrosome and coordinate the initiation of ciliogenesis.
PIPKIgamma, downstream of EGF (zeige EGF ELISA Kits) and/or HGF receptor, participates in breast cancer progression
Shp1 binds and controls PIPKIgamma activity and, thereby, modulates phosphatidylinositol (4,5)-bisphosphate levels and adhesion.
The results of this study suggest that PIP5KIgamma, especially PIP5KIgamma_i2, is localized at the periactive zone, a functionally suitable compartment for the endocytosis of synaptic vesicles in photoreceptor ribbon synapses.
The lipid kinase PIP5K1C regulates pain signaling and sensitization in mice.
The findings suggest an essential role of PIP5KIgamma, particularly PIP5KIgamma_i2, in neuronal migration, possibly through recruitment of adhesion components to the plasma membrane.
Although PIP5KIgamma is essential for normal platelet function, individual isoforms of PIP5KIgamma fulfill unique roles for the integrin-dependent integrity of the membrane cytoskeleton and for the stabilization of platelet adhesion.
NMDA receptor activation controls AMPA AMPA AMPA (zeige GRIA3 ELISA Kits) receptor endocytosis during hippocampal LTD by regulating PIP5Kgamma661 activity at postsynapses.
PIP5KIgamma-mediated generation of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) at sites of N-cadherin (zeige CDH2 ELISA Kits) contacts regulates intercellular adhesion strength, an effect due in part to PI(4,5)P2-mediated regulation of gelsolin (zeige GSN ELISA Kits).
PIP5K1C-90 polarization was required for polarized RhoA activation at uropods and provided an initial directional cue for neutrophil polarization on the endothelium.
This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
Human homolog of mouse phosphatidylinositol-4-phosphate 5-kinase I-gamma
, diphosphoinositide kinase
, phosphatidylinositol 4-phosphate 5-kinase type I gamma
, phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
, phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
, ptdIns(4)P-5-kinase 1 gamma
, type I PIP kinase
, phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
, ptdIns(4)P-5-kinase gamma
, phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
, phosphatidylinositol-4-phosphate 5-kinase type I gamma