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Both PIK3CA mutants H1047R and E545K are able to activate the AKT/mTOR pathway. An intact AKT2/mTOR complex 1 cascade is required for tumourigenesis induced by H1047R/c-Met or E545K/c-Met in the liver in mice.
Loss of HDAC (zeige HDAC3 ELISA Kits)-mediated repression and gain of NF-kappaB (zeige NFKB1 ELISA Kits) activation underlie cytokine induction in ARID1A (zeige ARID1A ELISA Kits)- and PIK3CA-mutation-driven ovarian cancer.
We further demonstrate that loss of one allele of PTEN is sufficient to shift isoform dependency from p110alpha to p110beta in vivo. These results provide insight into the molecular mechanism by which ErbB2 (zeige ERBB2 ELISA Kits)-positive breast cancer escapes p110alpha inhibition.
Studies indicate that the Pten+/- genotype displayed neoplasia in multiple organs, including the endometrium and that the Pten is a key regulatory player in the PI3K/PTEN/AKT (zeige AKT1 ELISA Kits) pathway.
our results offer significant insight into how PIK3CA overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 (zeige PDPK1 ELISA Kits) and TGFb (zeige TGFB1 ELISA Kits) signaling in advanced HNSCC patients with PIK3CA amplification
Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 (zeige HSP90 ELISA Kits) and the PI3K/AKT (zeige AKT1 ELISA Kits)/mTOR (zeige FRAP1 ELISA Kits) pathway in prostate cancer.
Data indicate that chlorogenic acid (CGA (zeige CGA ELISA Kits)) protected osteoblast MC3T3-E1 cells against oxidative damage via PI3K/Akt (zeige AKT1 ELISA Kits)-mediated activation of Nrf2 (zeige NFE2L2 ELISA Kits)/HO-1 (zeige HMOX1 ELISA Kits) pathway, which may be an effective drug in treatment of osteoporosis.
Data show that macrophage M2 polarization was mediated through PTEN/PI3k/AKT (zeige AKT1 ELISA Kits) pathway activation.
Constitutive Activation of PI3K is associated with Ovarian Granulosa Cell Tumors.
Together with recent identification of somatic mutations in p110a (encoded by PIK3CA), our data establish a potential mechanistic link between AGGF1 (zeige AGGF1 ELISA Kits) and PIK3CA, the two genes identified for Klippel-Trenaunay syndrome (KTS)
Study found that PIK3CA mutation occurred in approximately 2.8% of patients with lung adenocarci- noma in a cohort of Chinese patients.
PIK3CA mutations are associated with esophageal squamous cell carcinoma.
This is the first report on phosphorylation of p53 (zeige TP53 ELISA Kits) serine 46 as a modulator of p53 (zeige TP53 ELISA Kits)-PIK3CA promoter interaction.
KRAS mutations and AKT (zeige AKT1 ELISA Kits) activation are present in Wilms tumors (WT) and may represent novel therapeutic targets for this tumor.
relevant genomic aberrations such as mutations in the hotspot regions of exon 9 and 20 of the PIK3CA gene can be detected in single circulating tumor cells and might provide insights into mechanisms of resistance to HER2 (zeige ERBB2 ELISA Kits)-targeted therapies.
the expression of 3 miRs and 9 mRNAs associate with the PIK3CA status. Expression of LRG1 (zeige LRG1 ELISA Kits) is independent of luminal (A or B) subtype, decreased after neo-adjuvant aromatase (zeige CYP19A1 ELISA Kits) inhibitor treatment.
Somatic mutations affecting PI3K pathway genes were found to be highly prevalent in infiltrating epitheliosis, suggesting that these lesions may be neoplastic rather than hyperplastic.
Somatic PIK3CA mutations in seven patients with PIK3CA-related overgrowth spectrum have been reported.
These results indicated that dual targeting of PI3K and PERK pathways might improve clinical prognosis and enhance the treatment of ESCC patients.
These data indicate that increased irisin (zeige FNDC5 ELISA Kits) levels may have protective roles in liver cancer cells through partial activation of the PI3K/AKT (zeige AKT1 ELISA Kits) pathway, which may facilitate liver cancer progression and decrease the sensitivity to chemotherapy.
There are multiple conformations in equilibrium during the course of PI3K SH3 domain (zeige ITSN1 ELISA Kits) unfolding.
PI3K has a role in activation of 5'-AMP (zeige TMPRSS5 ELISA Kits)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells
Production of PtdIns3P by PI3K-C2alpha (zeige PIK3C2A ELISA Kits) is required for acquisition of fusion competence in neurosecretion.
crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
phosphoinositide-3-kinase, catalytic, alpha polypeptide
, Phosphoinositide-3-kinase, catalytic, alpha polypeptide
, PI3-kinase subunit alpha
, phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
, phosphoinositide-3-kinase catalytic alpha polypeptide
, ptdIns-3-kinase subunit alpha
, ptdIns-3-kinase subunit p110-alpha
, serine/threonine protein kinase PIK3CA
, PI3-kinase p110 subunit alpha
, phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha
, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform
, ptdIns-3-kinase p110
, phosphoinositide 3-kinase catalytic subunit