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conclude that cross-talk between PTEN and PHLPPs is silenced in normal prostate cells but activated in TGF-beta1 (zeige TGFB1 ELISA Kits) transformed prostate stem and cancer cells and facilitates invasive growth
Low PHLPP expression is associated with gallbladder cancer.
nickel exposure results in DNMT3b (zeige DNMT3B ELISA Kits) induction and MEG3 (zeige FAM129B ELISA Kits) promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun (zeige JUN ELISA Kits) and in turn increasing c-Jun (zeige JUN ELISA Kits) inhibition of PHLPP1 transcription, leading to the Akt (zeige AKT1 ELISA Kits)/p70S6K (zeige RPS6KB1 ELISA Kits)/S6 axis activation, and HIF-1alpha (zeige HIF1A ELISA Kits) protein translation, as well as malignant transformation of human bronchial epithelial cells.
Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41 (zeige RNF41 ELISA Kits)-mediated SGT1 (zeige SUGT1 ELISA Kits) degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 (zeige RNF41 ELISA Kits) = ring finger protein 41 (zeige RNF41 ELISA Kits); SGT1 (zeige SUGT1 ELISA Kits) = suppressor of G2 allele of SKP1 (zeige SUGT1 ELISA Kits))
Studies indicate that two PHLPP isozymes, PHLPP1 and PHLPP2, were identified in a search for phosphatases that dephosphorylate Akt (zeige AKT1 ELISA Kits), and thus suppress growth factor signaling.
During LPS (zeige IRF6 ELISA Kits) induced macrophage inflammatory response, PHLPP levels in macrophages are depleted through the inhibition of SP1 (zeige PSG1 ELISA Kits) dependent transcriptional regulation.
results identify a novel role of PHLPP in regulating aPKC and cell polarity.
Abnormal PHLPP, FoxO3a (zeige FOXO3 ELISA Kits), and RAD51 (zeige RAD51 ELISA Kits) protein expressions may be involved in the development of high- and low-grade ovarian serous adenocarcinomas, suggesting common molecular pathways.
this study shows that PHLPP1 played a suppression role in inflammatory response of glioma
Increased PHLPP expression is associated with pancreatic cancer.
PHLPP1 reduced IFN-gamma (zeige IFNG ELISA Kits)-stimulated but not LPS (zeige TLR4 ELISA Kits)-induced ERK1/2 (zeige MAPK1/3 ELISA Kits) phosphorylation, and inhibition of ERK1/2 (zeige MAPK1/3 ELISA Kits) abolished IFN-gamma-induced (zeige SAMHD1 ELISA Kits) ser (zeige SIGLEC1 ELISA Kits)(727) STAT1 (zeige STAT1 ELISA Kits) phosphorylation and iNOS (zeige NOS2 ELISA Kits) expression.
Phlpp1 deficiency increases Akt2 (zeige AKT2 ELISA Kits) activity, which diminishes FoxO1 (zeige FOXO1 ELISA Kits) levels and induces Fgf18 (zeige FGF18 ELISA Kits) expression to stimulate chondrocyte proliferation.
enhancing Akt (zeige AKT1 ELISA Kits) activity by inhibiting its PHLPP1-mediated dephosphorylation promotes processes associated with physiological hypertrophy
data are consistent with a model in which PHLPP modifies the histone code to control the transcription of RTKs.
SRPK1 (zeige SRPK1 ELISA Kits) overexpression is also tumorigenic because excess SRPK1 (zeige SRPK1 ELISA Kits) squelches PHLPP1.
PHLPP is a negative regulator of RAF1 (zeige RAF1 ELISA Kits), which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Histone deacetylase 3 (zeige HDAC3 ELISA Kits) suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt (zeige AKT1 ELISA Kits) signaling and matrix secretion
deletion of PHLPP1 can enhance Akt (zeige AKT1 ELISA Kits) activation in neurons and astrocytes, and can significantly increase cell survival and diminish infarct size
PHLPP1 has tumor suppressive activity and might represent a therapeutic or diagnostic tool for pancreatic ductal adenocarcinoma.
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
PH domain and leucine rich repeat protein phosphatase 1
, PH domain leucine-rich repeat-containing protein phosphatase 1-like
, PH domain leucine-rich repeat-containing protein phosphatase 1
, PH domain-containing family E member 1
, SCN circadian oscillatory protein
, pleckstrin homology domain containing, family E (with leucine rich repeats) member 1
, suprachiasmatic nucleus circadian oscillatory protein
, pleckstrin homology domain-containing family E member 1
, Circadian Oscillatory Protein (SCOP)
, PH domain leucine-rich repeat protein phosphatase 1
, pleckstrin homology domain-containing family E protein 1