PHLPP1 (PHLPP1) ELISA Kits

Bezeichnung:
PH Domain and Leucine Rich Repeat Protein Phosphatase 1 ELISA Kits (PHLPP1)
Auf www.antikoerper-online.de finden Sie aktuell 0 PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) ELISA Kits von unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PHLPP1 Antikörper (36) und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 43 PHLPP1 Produkte verfügbar.
Synonyme:
AI836256, mKIAA0606, Phlpp, Plekhe1, Scop
list all ELISA KIts Gen GeneID UniProt
Human PHLPP1 PHLPP1 23239 O60346
Maus PHLPP1 PHLPP1 98432 Q8CHE4
Ratte PHLPP1 PHLPP1 59265 Q9WTR8

Weitere Synonyme anzeigen

Weitere ELISA Kits für PHLPP1 Interaktionspartner

Human PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) Interaktionspartner

  1. nickel exposure results in DNMT3b (zeige DNMT3B ELISA Kits) induction and MEG3 (zeige FAM129B ELISA Kits) promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun (zeige JUN ELISA Kits) and in turn increasing c-Jun (zeige JUN ELISA Kits) inhibition of PHLPP1 transcription, leading to the Akt (zeige AKT1 ELISA Kits)/p70S6K (zeige RPS6KB1 ELISA Kits)/S6 axis activation, and HIF-1alpha (zeige HIF1A ELISA Kits) protein translation, as well as malignant transformation of human bronchial epithelial cells.

  2. Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41 (zeige RNF41 ELISA Kits)-mediated SGT1 (zeige SUGT1 ELISA Kits) degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 (zeige RNF41 ELISA Kits) = ring finger protein 41 (zeige RNF41 ELISA Kits); SGT1 (zeige SUGT1 ELISA Kits) = suppressor of G2 allele of SKP1 (zeige SUGT1 ELISA Kits))

  3. Studies indicate that two PHLPP isozymes, PHLPP1 and PHLPP2, were identified in a search for phosphatases that dephosphorylate Akt (zeige AKT1 ELISA Kits), and thus suppress growth factor signaling.

  4. During LPS (zeige IRF6 ELISA Kits) induced macrophage inflammatory response, PHLPP levels in macrophages are depleted through the inhibition of SP1 (zeige PSG1 ELISA Kits) dependent transcriptional regulation.

  5. results identify a novel role of PHLPP in regulating aPKC and cell polarity.

  6. Abnormal PHLPP, FoxO3a (zeige FOXO3 ELISA Kits), and RAD51 (zeige RAD51 ELISA Kits) protein expressions may be involved in the development of high- and low-grade ovarian serous adenocarcinomas, suggesting common molecular pathways.

  7. this study shows that PHLPP1 played a suppression role in inflammatory response of glioma

  8. Increased PHLPP expression is associated with pancreatic cancer.

  9. our results suggest that PHLPP1 plays a crucial role in sacral chordoma

  10. high levels of PHLPP might reflect a less aggressive lung adenocarcinoma phenotype and predict better survival in patients with lung adenocarcinoma.

Mouse (Murine) PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) Interaktionspartner

  1. results identify a novel role of PHLPP in regulating aPKC and cell polarity.

  2. Phlpp1 deficiency increases Akt2 (zeige AKT2 ELISA Kits) activity, which diminishes FoxO1 (zeige FOXO1 ELISA Kits) levels and induces Fgf18 (zeige FGF18 ELISA Kits) expression to stimulate chondrocyte proliferation.

  3. enhancing Akt (zeige AKT1 ELISA Kits) activity by inhibiting its PHLPP1-mediated dephosphorylation promotes processes associated with physiological hypertrophy

  4. data are consistent with a model in which PHLPP modifies the histone code to control the transcription of RTKs.

  5. SRPK1 (zeige SRPK1 ELISA Kits) overexpression is also tumorigenic because excess SRPK1 (zeige SRPK1 ELISA Kits) squelches PHLPP1.

  6. PHLPP is a negative regulator of RAF1 (zeige RAF1 ELISA Kits), which reduces colorectal cancer cell motility and prevents tumor progression in mice.

  7. Histone deacetylase 3 (zeige HDAC3 ELISA Kits) suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt (zeige AKT1 ELISA Kits) signaling and matrix secretion

  8. deletion of PHLPP1 can enhance Akt (zeige AKT1 ELISA Kits) activation in neurons and astrocytes, and can significantly increase cell survival and diminish infarct size

  9. PHLPP1 has tumor suppressive activity and might represent a therapeutic or diagnostic tool for pancreatic ductal adenocarcinoma.

  10. PHLPP as a novel tumor suppressor.

PHLPP1 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.

Alternative names and synonyms associated with PHLPP1

  • PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1) Elisa Kit
  • PH domain and leucine rich repeat protein phosphatase 1 (phlpp1) Elisa Kit
  • PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1) Elisa Kit
  • AI836256 Elisa Kit
  • mKIAA0606 Elisa Kit
  • Phlpp Elisa Kit
  • Plekhe1 Elisa Kit
  • Scop Elisa Kit

Bezeichner auf Proteinebene für PHLPP1

PH domain and leucine rich repeat protein phosphatase 1 , PH domain leucine-rich repeat-containing protein phosphatase 1-like , PH domain leucine-rich repeat-containing protein phosphatase 1 , PH domain-containing family E member 1 , SCN circadian oscillatory protein , pleckstrin homology domain containing, family E (with leucine rich repeats) member 1 , suprachiasmatic nucleus circadian oscillatory protein , pleckstrin homology domain-containing family E member 1 , Circadian Oscillatory Protein (SCOP) , PH domain leucine-rich repeat protein phosphatase 1 , pleckstrin homology domain-containing family E protein 1

GENE ID SPEZIES
468563 Pan troglodytes
476179 Canis lupus familiaris
705882 Macaca mulatta
100483835 Ailuropoda melanoleuca
100497530 Xenopus (Silurana) tropicalis
100545158 Meleagris gallopavo
23239 Homo sapiens
98432 Mus musculus
59265 Rattus norvegicus
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