anti-PHLPP1 (PHLPP1) Antikörper

Bezeichnung:
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 Antikörper (PHLPP1)
Auf www.antikoerper-online.de finden Sie aktuell 36 PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) Antikörper von 19 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 43 PHLPP1 Produkte verfügbar.
Synonyme:
AI836256, mKIAA0606, Phlpp, Plekhe1, Scop

Meistgesuchte Reaktivitäten zu anti-PHLPP1 (PHLPP1) Antikörper

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anti-Human PHLPP1 Antikörper:

anti-Mouse (Murine) PHLPP1 Antikörper:

anti-Rat (Rattus) PHLPP1 Antikörper:

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Am meisten referenzierte anti-PHLPP1 Antikörper

  1. Human Polyclonal PHLPP1 Primary Antibody für IP - ABIN151319 : Brognard, Niederst, Reyes, Warfel, Newton: Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. in The Journal of biological chemistry 2009 (PubMed)
    Zeige alle 7 Referenzen für 151319

  2. Human Polyclonal PHLPP1 Primary Antibody für IP, WB - ABIN151320 : Hirano, Nakamura, Yokota, Ono, Shigeno, Fujisawa, Shinjo, Ohnishi et al.: Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt ... in The Journal of biological chemistry 2009 (PubMed)
    Zeige alle 5 Referenzen für 151320

  3. Human Polyclonal PHLPP1 Primary Antibody für EIA, WB - ABIN360194 : Gao, Brognard, Newton: The phosphatase PHLPP controls the cellular levels of protein kinase C. in The Journal of biological chemistry 2008 (PubMed)
    Zeige alle 3 Referenzen für 360194

Weitere Antikörper gegen PHLPP1 Interaktionspartner

Human PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) Interaktionspartner

  1. nickel exposure results in DNMT3b (zeige DNMT3B Antikörper) induction and MEG3 (zeige FAM129B Antikörper) promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun (zeige JUN Antikörper) and in turn increasing c-Jun (zeige JUN Antikörper) inhibition of PHLPP1 transcription, leading to the Akt (zeige AKT1 Antikörper)/p70S6K (zeige RPS6KB1 Antikörper)/S6 axis activation, and HIF-1alpha (zeige HIF1A Antikörper) protein translation, as well as malignant transformation of human bronchial epithelial cells.

  2. Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41 (zeige RNF41 Antikörper)-mediated SGT1 (zeige SUGT1 Antikörper) degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 (zeige RNF41 Antikörper) = ring finger protein 41 (zeige RNF41 Antikörper); SGT1 (zeige SUGT1 Antikörper) = suppressor of G2 allele of SKP1 (zeige SUGT1 Antikörper))

  3. Studies indicate that two PHLPP isozymes, PHLPP1 and PHLPP2 (zeige PHLPP2 Antikörper), were identified in a search for phosphatases that dephosphorylate Akt (zeige AKT1 Antikörper), and thus suppress growth factor signaling.

  4. During LPS (zeige IRF6 Antikörper) induced macrophage inflammatory response, PHLPP levels in macrophages are depleted through the inhibition of SP1 (zeige PSG1 Antikörper) dependent transcriptional regulation.

  5. results identify a novel role of PHLPP in regulating aPKC and cell polarity.

  6. Abnormal PHLPP, FoxO3a (zeige FOXO3 Antikörper), and RAD51 (zeige RAD51 Antikörper) protein expressions may be involved in the development of high- and low-grade ovarian serous adenocarcinomas, suggesting common molecular pathways.

  7. this study shows that PHLPP1 played a suppression role in inflammatory response of glioma

  8. Increased PHLPP expression is associated with pancreatic cancer.

  9. our results suggest that PHLPP1 plays a crucial role in sacral chordoma

  10. high levels of PHLPP might reflect a less aggressive lung adenocarcinoma phenotype and predict better survival in patients with lung adenocarcinoma.

Mouse (Murine) PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) Interaktionspartner

  1. results identify a novel role of PHLPP in regulating aPKC and cell polarity.

  2. Phlpp1 deficiency increases Akt2 (zeige AKT2 Antikörper) activity, which diminishes FoxO1 (zeige FOXO1 Antikörper) levels and induces Fgf18 (zeige FGF18 Antikörper) expression to stimulate chondrocyte proliferation.

  3. enhancing Akt (zeige AKT1 Antikörper) activity by inhibiting its PHLPP1-mediated dephosphorylation promotes processes associated with physiological hypertrophy

  4. data are consistent with a model in which PHLPP modifies the histone code to control the transcription of RTKs.

  5. SRPK1 (zeige SRPK1 Antikörper) overexpression is also tumorigenic because excess SRPK1 (zeige SRPK1 Antikörper) squelches PHLPP1.

  6. PHLPP is a negative regulator of RAF1 (zeige RAF1 Antikörper), which reduces colorectal cancer cell motility and prevents tumor progression in mice.

  7. Histone deacetylase 3 (zeige HDAC3 Antikörper) suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt (zeige AKT1 Antikörper) signaling and matrix secretion

  8. deletion of PHLPP1 can enhance Akt (zeige AKT1 Antikörper) activation in neurons and astrocytes, and can significantly increase cell survival and diminish infarct size

  9. PHLPP1 has tumor suppressive activity and might represent a therapeutic or diagnostic tool for pancreatic ductal adenocarcinoma.

  10. PHLPP as a novel tumor suppressor.

PHLPP1 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.

Alternative names and synonyms associated with PHLPP1

  • PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1) Antikörper
  • PH domain and leucine rich repeat protein phosphatase 1 (phlpp1) Antikörper
  • PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1) Antikörper
  • AI836256 Antikörper
  • mKIAA0606 Antikörper
  • Phlpp Antikörper
  • Plekhe1 Antikörper
  • Scop Antikörper

Bezeichner auf Proteinebene für PHLPP1

PH domain and leucine rich repeat protein phosphatase 1 , PH domain leucine-rich repeat-containing protein phosphatase 1-like , PH domain leucine-rich repeat-containing protein phosphatase 1 , PH domain-containing family E member 1 , SCN circadian oscillatory protein , pleckstrin homology domain containing, family E (with leucine rich repeats) member 1 , suprachiasmatic nucleus circadian oscillatory protein , pleckstrin homology domain-containing family E member 1 , Circadian Oscillatory Protein (SCOP) , PH domain leucine-rich repeat protein phosphatase 1 , pleckstrin homology domain-containing family E protein 1

GENE ID SPEZIES
468563 Pan troglodytes
476179 Canis lupus familiaris
705882 Macaca mulatta
100483835 Ailuropoda melanoleuca
100497530 Xenopus (Silurana) tropicalis
100545158 Meleagris gallopavo
23239 Homo sapiens
98432 Mus musculus
59265 Rattus norvegicus
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