Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Select your species
Pyruvate dehydrogenase kinase 4 is a direct transcriptional target of FoxO1 (zeige FOXO1 ELISA Kits) in the heart. FoxO1 (zeige FOXO1 ELISA Kits) directly regulates Pdk4 transcription in the heart, thereby controlling PDH (zeige PDP ELISA Kits) activity and subsequent glucose oxidation rates.
inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1 (zeige CCNE1 ELISA Kits), cyclin A2 (zeige CCNA2 ELISA Kits), and E2F1 (zeige E2F1 ELISA Kits) proteins.
FXR (zeige NR1H4 ELISA Kits) may promote the proliferation of tumor cells and the hepatocytes in the process of liver regeneration by activating the PDK4-mediated metabolic reprogramming to generate glycolytic intermediates essential for rapid biomass generation, establishing a mechanistic link between cell proliferation and metabolic switch.
Taken together, our results suggest that LPS (zeige TLR4 ELISA Kits) induces PDK4 expression and alters glucose metabolism via the JNK (zeige MAPK8 ELISA Kits) pathway.
upregulation of PDK4 promotes vascular calcification by increasing osteogenic markers with no adverse effect on bone formation, demonstrating that PDK4 is a therapeutic target for vascular calcification.
PDK2 (zeige PDK2 ELISA Kits)/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy.
Double-knockout mice with global deletion of PDK2 (zeige PDK2 ELISA Kits) and PDK4, which results in constitutively activated pyruvate dehydrogenase (zeige PDP ELISA Kits), preferentially oxidize glucose in muscle.
PDK4 promotes tumorigenesis through activation of the CREB (zeige CREB1 ELISA Kits)-RHEB (zeige RHEB ELISA Kits)-mTORC1 signaling cascade.
Diminished insulin (zeige INS ELISA Kits) signaling evident at 1 wk on the high fat diet did not occur in pyruvate dehydrogenase kinase 4 knockout mice.
The Pdk4 gene knockdown led to better glucose tolerance than the Pdk2 (zeige PDK2 ELISA Kits) gene knockdown. Hepatic Pdk4 may be critically involved in the pathogenesis of diabetes.
Low PDK4 expression is associated with lung tumorigenesis.
Increased PDK4 expression is associated with colon cancer.
We found that PDK4 gene and protein expression was significantly elevated in pulmonary arterial hypertension pericytes and correlated with reduced mitochondrial metabolism, higher rates of glycolysis, and hyperproliferation
Inhibition of CK2 (zeige CSNK2A1 ELISA Kits) increased the expression of metabolic regulators, PDK4 and AMPK (zeige PRKAA1 ELISA Kits) along with the key cellular energy sensor CREB (zeige CREB1 ELISA Kits).
These findings indicate that the TGFbeta (zeige TGFB1 ELISA Kits)/PDK4 signaling axis plays an important role in the response of colorectal cancer to chemotherapy.
Combined speed endurance and endurance exercise amplify the exercise-induced PGC-1alpha (zeige PPARGC1A ELISA Kits) and PDK4 mRNA response in trained human muscle.
High PDK4 expression is associated with hepatocellular cancer.
Preoperative carbohydrate supplementation was found to ameliorate postoperative insulin (zeige INS ELISA Kits) sensitivity by reducing muscle inflammatory responses and improved insulin (zeige INS ELISA Kits) inhibition of FOXO1 (zeige FOXO1 ELISA Kits)-mediated PDK4 mRNA and protein expression after surgery.
Temporal and spatial expression analysis indicated that porcine PDK4 gene is highly expressed in skeletal muscle and the highest in neonatal pigs.
This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.
pyruvate dehydrogenase kinase 4
, pyruvate dehydrogenase kinase, isoenzyme 4
, pyruvate dehydrogenase kinase, isozyme 4
, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
, pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial
, pyruvate dehydrogenase kinase isozyme 4
, pyruvate dehydrogenate kinase 4