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anti-Mouse (Murine) PDK2 Antikörper:
anti-Human PDK2 Antikörper:
anti-Rat (Rattus) PDK2 Antikörper:
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Human Polyclonal PDK2 Primary Antibody für IHC (p), WB - ABIN391037
McClenaghan, Scullion, Mion, Hewage, Malthouse, Flatt, Newsholme, Brennan: Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells. in Clinical science (London, England : 1979) 2009
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Human Monoclonal PDK2 Primary Antibody für IHC (p), RNAi - ABIN562160
Babu, Deering, Mirmira: A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis. in Molecular genetics and metabolism 2007
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Human Polyclonal PDK2 Primary Antibody für FACS, IHC (p) - ABIN653784
Sun, Chang, Fu, Liu, Califano: Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1? stabilization. in PLoS ONE 2011
Show all 2 Pubmed References
Human Polyclonal PDK2 Primary Antibody für ICC, IF - ABIN4344598
Hou, Zhang, Han, Ge, Ma, Zhang, Moley, Schedl, Wang: Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation. in Journal of cell science 2015
The current study reports that increasing hepatic PDC (zeige PDC Antikörper) activity by inhibition of PDK2 ameliorates hepatic steatosis and insulin (zeige INS Antikörper) sensitivity by regulating TCA cycle anaplerosis and ketogenesis. The findings suggest PDK2 is a potential therapeutic target for nonalcoholic fatty liver disease.
PDK2/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy.
Double-knockout mice with global deletion of PDK2 and PDK4 (zeige PDK4 Antikörper), which results in constitutively activated pyruvate dehydrogenase (zeige PDP Antikörper), preferentially oxidize glucose in muscle.
The final compound of this series, 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits all four PDK isoforms with IC50 = 0.8 muM for PDK2.
The Pdk4 (zeige PDK4 Antikörper) gene knockdown led to better glucose tolerance than the Pdk2 gene knockdown.
loss of both Pdk2 and Pdk4 (zeige PDK4 Antikörper) attenuated HSC (zeige FUT1 Antikörper) quiescence, glycolysis, and transplantation capacity.
Results established that wild-type p53 (zeige TP53 Antikörper) prevents manifestation of the Warburg effect by controlling Pdk2. These findings elucidate a new mechanism by which p53 (zeige TP53 Antikörper) suppresses tumorigenesis acting at the level of cancer cell metabolism.
PDK2 activity is essential, even at rest, in regulation of carbohydrate oxidation and production of reducing equivalents for the electron transport chain.
mitochondrial ND2 (zeige MT-ND2 Antikörper) mutation contributes to HIF1alpha (zeige HIF1A Antikörper) accumulation via increased ROS (zeige ROS1 Antikörper) production, up-regulation of PDK2, attenuating PDH (zeige PDP Antikörper) activity, thereby increasing pyruvate, resulting in HIF1alpha (zeige HIF1A Antikörper) stabilization
The data demonstrate potential roles of PDK2 and ABCG2 (zeige ABCG2 Antikörper) polymorphisms in the metabolic phenotypes of Tibetan gout patients.
High glycolysis and PDK2 overexpression are closely linked to cisplatin resistance in head and neck cancer cells, which can be reversed by PDK2 nhibition.
both PDK 1 (zeige PDK1 Antikörper) and 2 isoforms are overexpressed in cutaneous melanoma compared to nevi, this expression being associated with the expression of the mTOR (zeige FRAP1 Antikörper) pathway effectors and independent of the BRAF (zeige BRAF Antikörper) mutational status
The findings of the present study reveal a novel survival pathway that functionally couples the unique glycolytic phenotype in cancer cells to hypoxia resistance via a PDK2-dependent mechanism that switches Bnip3 (zeige BNIP3 Antikörper) from cell death to survival.
Germline mutations in PKD2 (zeige PKD2 Antikörper) gene is associated with autosomal-dominant polycystic kidney disease.
we for the first time demonstrated that a low-nutrient condition drives cancer cells to utilize glycolysis to produce ATP, and this increases the Warburg effect through a novel mechanism involving ROS (zeige ROS1 Antikörper)/AMPK (zeige PRKAA1 Antikörper)-dependent activation of PDK.
Mitochondrial activation by inhibition of PDKII suppresses HIF1a (zeige HIF1A Antikörper) signaling and angiogenesis in cancer.
Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species.
This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
pyruvate dehydrogenase kinase 2
, pyruvate dehydrogenase kinase, isoenzyme 2
, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial
, pyruvate dehydrogenase kinase, isozyme 2
, PDH kinase 2
, pyruvate dehydrogenase 2
, pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial
, PDK P45
, pyruvate dehydrogenase kinase 2 subunit p45 (PDK2)