MAPKAP1 Proteine (MAPKAP1)

Bezeichnung:
Mitogen-Activated Protein Kinase Associated Protein 1 Proteine (MAPKAP1)
Auf www.antikoerper-online.de finden Sie aktuell 4 Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) Proteine von 2 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MAPKAP1 Antikörper (85) und MAPKAP1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 103 MAPKAP1 Produkte verfügbar.
Synonyme:
AI591529, CG10105, D230039K05Rik, Dmel\\CG10105, dSin1, im:7143088, JC310, MAPKAP1, MGC53034, MIP1, si:ch73-242f23.1, Sin1, SIN1b, SIN1g
alle Proteine anzeigen Gen GeneID UniProt
MAPKAP1 79109 Q9BPZ7
MAPKAP1 227743 Q8BKH7
Ratte MAPKAP1 MAPKAP1 296648 Q6AYF1

Weitere Synonyme anzeigen

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Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) Interaktionspartner

  1. Sin1, Rictor, Trc and target of rapamycin (TOR), components of the TOR complex 2 (TORC2), are required for dendritic tiling of class IV da neurons

Human Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) Interaktionspartner

  1. SIN1 plays an important role in non-small cell lung cancer; SIN1 is a potential biomarker and a promising target in the treatment of NSCLC

  2. This study provides evidence that Sin1, a known element of the mammalian target of rapamycin (zeige FRAP1 Proteine) complex 2 (mTORC2 (zeige CRTC2 Proteine)), is required for Interferon-gamma (zeige IFNG Proteine)-induced phosphorylation and activation of AKT (zeige AKT1 Proteine) and that such activation mediates downstream regulation of mTORC1 and its effectors.

  3. Intracellular localization of mTORC2 (zeige CRTC2 Proteine) component, mSin1, contributes to regulation of Akt (zeige AKT1 Proteine) phosphorylation.

  4. Akt (zeige AKT1 Proteine) phosphorylates SIN1 at T86, enhancing mTORC2 (zeige CRTC2 Proteine) kinase activity, which leads to phosphorylation of Akt (zeige AKT1 Proteine) S473 by mTORC2 (zeige CRTC2 Proteine), thereby catalyzing full activation of Akt (zeige AKT1 Proteine).

  5. MAPKAP1 may represent a novel anti-infection and anti-fibrogenesis genomic locus in chronic schistosomiasis japonica.

  6. mitogen-activated protein kinase associated protein 1 rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma.

  7. DNA-PKcs (zeige PRKDC Proteine)-mTORC2 (zeige CRTC2 Proteine)(SIN1) association is required for UVB-induced Akt (zeige AKT1 Proteine) Ser (zeige SIGLEC1 Proteine)-473 phosphorylation and cell survival.

  8. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient lymphangioleiomyomatosis cells.

  9. results reveal a Sin1-phosphorylation-dependent mTORC2 (zeige CRTC2 Proteine) regulation, providing a potential molecular mechanism by which mutations in the mTORC1-S6K (zeige RPS6KB1 Proteine)-Sin1 signalling axis might cause aberrant hyper-activation of the mTORC2 (zeige CRTC2 Proteine)-Akt (zeige AKT1 Proteine) pathway

  10. NBS1 (zeige NBN Proteine) interacts with the mTOR (zeige FRAP1 Proteine)/Rictor/SIN1 complex through the a.a. 221-402 domain and contributes to the activation of Akt (zeige AKT1 Proteine) activity.

Mouse (Murine) Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) Interaktionspartner

  1. This study provides evidence that Sin1, a known element of the mammalian target of rapamycin (zeige FRAP1 Proteine) complex 2 (mTORC2 (zeige CRTC2 Proteine)), is required for Interferon-gamma (zeige IFNG Proteine)-induced phosphorylation and activation of AKT (zeige AKT1 Proteine) and that such activation mediates downstream regulation of mTORC1 and its effectors.

  2. analysis of mTORC2 components mTOR, Rictor and mSin1 reveals diurnal variation in mouse perivascular adipose tissue

  3. data suggest that DNA-PKcs (zeige PRKDC Proteine)-SIN1 complexation-mediated Akt (zeige AKT1 Proteine) activation (Ser (zeige SIGLEC1 Proteine)-473 phosphorylation) is required for mouse osteoblast differentiation

  4. these findings provide evidence for critical functions for Rictor/Sin1 complexes in type I IFN signaling and the generation of type I IFN antineoplastic responses.

  5. The phosphorylation of SIN1 by Akt (zeige AKT1 Proteine) was found to regulate mTORC2 (zeige CRTC2 Proteine) activity in response to growth factors, revealing topological insights into the Akt (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) signaling network.

  6. Sin1 and mTORC2 (zeige CRTC2 Proteine) are dispensable for the development and activation of T cells but play a role in nTreg-cell differentiation.

  7. mSIN1 protein mediates SGK1 (zeige SGK1 Proteine) protein interaction with mTORC2 (zeige CRTC2 Proteine) protein complex and is required for selective activation of the epithelial sodium channel

  8. MAP kinase (zeige MAPK1 Proteine)-interacting kinase 1 and 2 activity enhances formation of the EIF-4F complex in pachytene spermatocytes but not in round spermatids.

  9. Sin1-mTORC2 (zeige CRTC2 Proteine) suppresses rag1,2 and il7r (zeige IL7R Proteine) gene expression through Akt2 (zeige AKT2 Proteine) in B cells.

  10. Results reveal that the SIN1-rictor-mTOR (zeige FRAP1 Proteine) function in Akt (zeige AKT1 Proteine)-Ser473 phosphorylation is required for TORC2 (zeige CRTC2 Proteine) function in cell survival but is dispensable for TORC1 (zeige CRTC1 Proteine) function.

MAPKAP1 Protein Überblick

Protein Überblick

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.

Alternative names and synonyms associated with MAPKAP1

  • SAPK-interacting protein 1 (Sin1)
  • mitogen-activated protein kinase associated protein 1 (MAPKAP1)
  • mitogen-activated protein kinase associated protein 1 (mapkap1)
  • mitogen-activated protein kinase associated protein 1 (Mapkap1)
  • AI591529 Protein
  • CG10105 Protein
  • D230039K05Rik Protein
  • Dmel\\CG10105 Protein
  • dSin1 Protein
  • im:7143088 Protein
  • JC310 Protein
  • MAPKAP1 Protein
  • MGC53034 Protein
  • MIP1 Protein
  • si:ch73-242f23.1 Protein
  • Sin1 Protein
  • SIN1b Protein
  • SIN1g Protein

Bezeichner auf Proteinebene für MAPKAP1

CG10105-PA , Sin1-PA , Stress-activated protein kinase [SAPK]-interacting protein , stress-activated map kinase-interacting protein 1 , mitogen-activated protein kinase associated protein 1 , Target of rapamycin complex 2 subunit MAPKAP1 , target of rapamycin complex 2 subunit MAPKAP1-like , MEKK2-interacting protein 1 , SAPK-interacting protein 1 , TORC2 subunit MAPKAP1 , mSIN1 , mitogen-activated protein kinase 2-associated protein 1 , ras inhibitor MGC2745 , stress-activated map kinase interacting protein 1 , stress-activated protein kinase-interacting 1 , target of rapamycin complex 2 subunit MAPKAP1 , mitogen activated protein kinase associated protein 1 , SAPK interacting protein

GENE ID SPEZIES
36604 Drosophila melanogaster
464736 Pan troglodytes
480724 Canis lupus familiaris
492604 Danio rerio
100101680 Xenopus (Silurana) tropicalis
100390680 Callithrix jacchus
100481486 Ailuropoda melanoleuca
100601949 Nomascus leucogenys
79109 Homo sapiens
227743 Mus musculus
296648 Rattus norvegicus
533861 Bos taurus
395627 Gallus gallus
380158 Xenopus laevis
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