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role of p105 (zeige CDH13 ELISA Kits)/Tpl2 signaling in lung homeostasis
rs1042058 GG Crohn's disease -risk polymorphism in TPL2 results in a gain-of-function by increasing TPL2 expression and signalling, thereby amplifying Pattern recognition receptor -initiated outcomes.
MAP3K8 is a direct target of miR (zeige MLXIP ELISA Kits)-144-3p, and miR (zeige MLXIP ELISA Kits)-144-3p downregulation is a factor in renal cell carcinoma progression through potentiation of MAP3K8 expression.
Taken together, these results suggest that Cot kinase might play a critical role in Helicobacter pylori type IV secretion apparatus-dependent early IL-8 (zeige IL8 ELISA Kits) secretion and CagA (zeige S100A8 ELISA Kits)-dependent late IL-8 (zeige IL8 ELISA Kits) secretion as an alternative signaling molecule in the Erk (zeige EPHB2 ELISA Kits) pathway.
Studies indicate that Tpl2, a MAP3K, participates in a broad range of cancer-related signaling pathways and induces tumorigenesis and progression of many cancers.
the results of the present study demonstrated that the miR-509-3p RCC suppressor was a significant regulator of the MAP3K8 oncogene, suggesting that it may have a potential therapeutic role in the treatment of renal cell carcinoma
findings provide a novel perspective on the role of the IL-33 (zeige IL33 ELISA Kits)/ST2 (zeige SULT2A1 ELISA Kits)/COT signaling pathway in supporting cancer-associated inflammation in the tumor microenvironment
structurally versatile active site significantly impacts the design of potent, low molecular weight COT kinase inhibitors
TPL2 mediates the phosphorylation of a fraction of nucleophosmin (zeige NPM1 ELISA Kits) at threonine 199, an event required for its proteasomal degradation and maintenance of steady-state nucleophosmin (zeige NPM1 ELISA Kits) levels.
MAP3K8 and miR-17-5p expression were inversely correlated with treatment response
study to determine whether Tpl2 influences the immune response generated to the extracellular bacterium Citrobacter rodentium, which induces a mixed Th1 (zeige HAND1 ELISA Kits) and Th17 response; findings confirm the importance of Tpl2 in driving the development of the proinflammatory Th1 (zeige HAND1 ELISA Kits) lineage as well as promoting IL-17A (zeige IL17A ELISA Kits) expression and neutrophil recruitment during infection with extracellular bacteria
TPL-2-regulated Ccl24 (zeige CCL24 ELISA Kits) in CD11c (zeige ITGAX ELISA Kits)+CD11b (zeige ITGAM ELISA Kits)+ cells prevents accelerated type-2 mediated immunity to H. polygyrus.
role of p105 (zeige NEDD9 ELISA Kits)/Tpl2 signaling in lung homeostasis
this study shows that TPL-2 deficiency leads to severe house duct mite-induced airway allergy, when compared with wild-type mice
The kinase TPL2 activates ERK (zeige EPHB2 ELISA Kits) and p38 (zeige CRK ELISA Kits) signaling to promote neutrophilic inflammation
TPL2 kinase is a crucial signaling factor in iNKT cells and major mediator of hepatic inflammation.
Taken together this study identified that TPL-2 regulated TH2-mediated inflammation by supporting lipolysis and M2 macrophage activation, preventing TH2 cell expansion and downstream immunopathology and fibrosis.
Map3k8 decreases apoptosis of monocytes and enhances CCR2 (zeige CCR2 ELISA Kits) expression on Ly6C(high)CD11c (zeige ITGAX ELISA Kits)(low) monocytes of atherosclerotic ApoE (zeige APOE ELISA Kits)(-/-) mice fed an high fat diet.
results demonstrate that Tpl2 promotes inflammation in part by constraining FoxP3 (zeige FOXP3 ELISA Kits) expression and Treg immunosuppressive functions.
Tpl2 plays a significant role in promoting HCC (zeige FAM126A ELISA Kits) development by its pro-inflammatory effect, which suggested that Tpl2 could be a molecular target for HCC (zeige FAM126A ELISA Kits) prevention.
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.
mitogen-activated protein kinase kinase kinase 8
, Ewing sarcoma transformant
, cot (cancer Osaka thyroid) oncogene
, proto-oncogene c-Cot
, proto-oncogene serine/threoine protein kinase
, tumor progression locus 2
, COT proto-oncogene serine/threonine-protein kinase
, cancer Osaka thyroid oncogene
, cancer Osaka thyroid, oncogene
, mitogen activated protein kinase kinase kinase 8
, serine/threonine-protein kinase cot
, serine/threonine kinase (Tpl-2)