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This study demonstrated that a significant decrease in the protein level of GluN2A (zeige GRIN2A Proteine) in major depression disorder.
both the intracellular C-terminal domain (CTD) and the loop region between the M1 and M2 helices move during activation and the CTD is detached from the membrane
The results of this study suggest that neurons in hypothalamic hamartoma may bear Ca(2 (zeige CA2 Proteine)+) -permeable AMPA (zeige GRIA3 Proteine) receptors(GluA2 ) due to dislocation of ADAR2 (zeige ADARB1 Proteine)
A transient positive feedback mechanism between AMPAR and stargazin has implications for information processing in the brain, because it should allow activity-dependent facilitation of excitatory synaptic transmission through a postsynaptic mechanism.
The GluR2 subunit of the AMPA (zeige GRIA3 Proteine) receptor is involved in cell migration and calcium signaling.
RAB39B (zeige RAB39B Proteine) selectively regulates GluA2 trafficking to determine synaptic AMPAR composition
GRIA2*CCC polymorphism is genetic risk marker for paranoid schizophrenia in Russians.Low risk genetic markers of paranoid schizophrenia were revealed: in Tatars-GRIA2*T/T (rs43025506) of GRIA2 gene and GRIA2*CCT in Russians.
GRIA2 is a useful marker for distinguishing solitary fibrous tumour from most mimics
a link between neurodegenerative processes and deficient RNA editing of the GluA2 Q/R site.
the levels were comparable for complexes containing GluR2, GluR3 (zeige GRIA3 Proteine) and GluR4 (zeige GRIA4 Proteine) as well as 5-HT1A (zeige HTR1A Proteine). Moreover, the levels of complexes containing muscarinic AChR M1, NR1 (zeige GRIN1 Proteine) and GluR1 (zeige GRIA1 Proteine) were significantly increased in male patients with AD.
Results indicate that disrupting GluA2 phosphorylation and increasing GluA2-mediated transmission in the nucleus accumbens leads to increased vulnerability to cocaine relapse.
Chronic stress-elicited depressive behavior may be due to hypertrophy of basolateral amygdala (BLA (zeige LACTB Proteine)) neuronal dendrites and increased of Glur1 (zeige GRIA1 Proteine)-Glur2 ratio in BLA (zeige LACTB Proteine) neurons.
found the protein levels of AMPA (zeige GRIA3 Proteine) receptor subunits (GluR1 (zeige GRIA1 Proteine) and GluR2) are upregulated in the amygdala and the 5-HT3 receptor (zeige HTR3A Proteine) is downregulated in hypothalamic regions of Socially Isolated mice.
These results provide direct evidence for cortical AMPA (zeige GRIA3 Proteine) receptors to contribute to zymosan-induced visceral and spontaneous pain.
Animals trained in the trace fear conditioning protocol had GluA2 RNA editing levels were nearly 100% in amygdala and hippocampus.
These results provide evidence for VPS35 (zeige vps35 Proteine)'s function in promoting spine maturation, which is likely through increasing AMPA (zeige GRIA3 Proteine) receptor targeting to the postsynaptic membrane.
Bacopa monnieri extract (CDRI-08) upregulates the expression of the GluR2 subunit in the CA3 (zeige CA3 Proteine) area of the hippocampus.
subcellular redistribution of GRIP1 (zeige NCOA2 Proteine) and a change in the binding of GRIP1 (zeige NCOA2 Proteine) to GluA2 during synaptic scaling, was observed.
Data indicate that the AMPA (zeige GRIA3 Proteine) receptor subunits abundance is hippocampus, GluA2 > GluA1 (zeige GRIA1 Proteine) > GluA3 (zeige GRIA3 Proteine) >> GluA4 (zeige GRIA4 Proteine); cortex, GluA2 > GluA3 (zeige GRIA3 Proteine) >/= GluA1 (zeige GRIA1 Proteine) >> GluA4 (zeige GRIA4 Proteine); and cerebellum, GluA2 > GluA3 (zeige GRIA3 Proteine) >/= GluA1 (zeige GRIA1 Proteine) > GluA4 (zeige GRIA4 Proteine).
Loss of long-term potentiation was linked to reduced N-methyl-D-aspartate (NMDA) to alpha-amino-3-hydroxy- 5-methyl-4-isoxazolepropionic acid (AMPA (zeige GRIA3 Proteine)) current ratio.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG\; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
AMPA-selective glutamate receptor 2
, Glutamate receptor 2
, glutamate receptor ionotropic, AMPA 2
, glutamate receptor 2
, glutamate receptor B
, AMPA glutamate receptor 2
, AMPA receptor GluR2/B
, AMPA selective glutamate receptor
, glutamate receptor AMPA 2