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some cancer cells are defective for efficient interaction between p27 (zeige PAK2 ELISA Kits) and CycA-CDK (zeige CDK4 ELISA Kits) complex due to qualitative alteration(s)
This study shows that cocaine induces significant increases in both the astrocytic expression of cyclin A2 and the proliferation of primary human astrocytes.
Low CCNA expression is associated with lung cancer progression.
cyclin D1 (zeige CCND1 ELISA Kits) and other cyclins such as cyclin A regulates DNA integrity through RAD51 (zeige RAD51 ELISA Kits) interaction with the BRCA2 (zeige BRCA2 ELISA Kits) C-terminal domain
inhibition of PDK4 (zeige PDK4 ELISA Kits) activity in Hepatocellular carcinoma cells increased cyclin E1 (zeige CCNE1 ELISA Kits), cyclin A2, and E2F1 (zeige E2F1 ELISA Kits) proteins.
An increase of cyclin A2 expression was identified for the first time in a case of splenic diffuse red pulp small B-cell lymphoma.
Consistent with these findings, a genome-scale pooled RNA interference screen revealed that toxic doses of MK-1775 are suppressed by CDK2 (zeige CDK2 ELISA Kits) or Cyclin A2 knockdown. These findings support G2 exit as the more significant effect of Wee1 (zeige WEE1 ELISA Kits) inhibition in pancreatic cancers.
Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21 (zeige CDKN1A ELISA Kits), p27 (zeige PAK2 ELISA Kits)-cyclin E (zeige CCNE1 ELISA Kits),A/Cdk2 (zeige CDK2 ELISA Kits) pathway.
On analyzing cyclin A and B1 (CCNA and CCNB1 (zeige CCNB1 ELISA Kits)) expression, positive staining in 90% cases of PTC (zeige F9 ELISA Kits) were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC (zeige F9 ELISA Kits).
Study describes a positive feedback loop centred on cyclin A2-Cdk2 (zeige CDK2 ELISA Kits) inhibition of interphase APC (zeige APC ELISA Kits)/C-Cdc20 (zeige CDC20 ELISA Kits) to allow further cyclin A2 accumulation and mitotic entry.
We demonstrate that CCNA2-null progenitors suffer abnormal DNA repair, and implicate Cyclin A2 in double-strand break repair. Cyclin A2's DNA repair functions are conserved among cell lines, neural progenitors, and hippocampal neurons. We further demonstrate that neuronal CCNA2 ablation results in learning and memory deficits in aged mice.
cyclin A2 mediates the fidelity ofmeiosis II by maintaining microtubule dynamics during the rapid formation of the meiosis II spindle.
These data unveils the critical functions of cyclin A2 in regulating mammalian erythropoiesis.
Meioc-deficient spermatocytes that have initiated synapsis mis (zeige AMH ELISA Kits)-express CYCLIN A2, which is normally expressed in mitotic spermatogonia, suggesting a failure to properly transition to a meiotic cell cycle program.
cyclin A2 controlled Mre11 (zeige MRE11A ELISA Kits) abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 (zeige MRE11A ELISA Kits) transcripts to mediate polysome loading and translation.
hese data suggest that mmu-miR (zeige MLXIP ELISA Kits)-125b decreases NO production in activated macrophages at least partially by suppressing eEF2K (zeige EEF2K ELISA Kits) and CCNA2 expression.
Cyclin A2 modulates epithelial-mesenchymal transition via beta-catenin (zeige CTNNB1 ELISA Kits) and phospholipase C (zeige PLC ELISA Kits) pathways.
Ccn2 (zeige CTGF ELISA Kits) is a regulator of the transition through cytokinesis during terminal erythropoiesis.
Loss of CCNA2 decreases cell proliferation and induces cerebellar cortical dyslamination.
B-Myb (zeige MYBL2 ELISA Kits) represses SMC (zeige DYM ELISA Kits) elastin (zeige ELN ELISA Kits) gene expression and cyclin A plays a role in the developmental regulation of elastin (zeige ELN ELISA Kits) gene expression in the aorta
inconstant elongation of the poly(A) tail was observed for cyclin A2 transcripts after maturation
an essential role for UHRF1 (zeige UHRF1 ELISA Kits) phosphorylation by cyclin-dependent kinase 2 (zeige CDK2 ELISA Kits)/cyclin A2 during early vertebrate development
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
, cyclin A
, cyclin A2
, Cyclin A2 (Cyclin A)