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Data show that IKKalpha directly bind to the promoters of LGR5 (zeige LGR5 ELISA Kits), in turn, upregulating LGR5 (zeige LGR5 ELISA Kits) expression through activation of STAT3 (zeige STAT3 ELISA Kits) signaling pathway during cancer progression.
single-particle cryoelectron microscopy (cryo-EM) and X-ray crystal structures of human IKK1 in dimeric ( approximately 150 kDa) and hexameric ( approximately 450 kDa) forms, are reported.
results suggest that changes in the relative concentrations of RelB, NIK:IKK1, and p100 during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100.
IKKalpha-dependent phosphorylation of S376 stimulated whereas IKKalpha-independent phosphorylation of S484 inhibited RORgammat function in Th17 differentiation.
Akt2 (zeige AKT2 ELISA Kits), Erk2 (zeige MAPK1 ELISA Kits), and IKK1/2 phosphorylate Bcl3 (zeige BCL3 ELISA Kits), converting Bcl3 (zeige BCL3 ELISA Kits) into a transcriptional coregulator by facilitating its recruitment to DNA.
IKKalpha promotes migration through dynamic interactions with the EGF (zeige EGF ELISA Kits) promoter depending on the redox state within cells.
the dual regulation of STAT1 (zeige STAT1 ELISA Kits) by IKKalpha in antiviral signaling suggests a role for IKKalpha in the fine-tuning of antiviral signaling in response to non-self RNA.
In epithelial ovarian cancer cells, miR (zeige MLXIP ELISA Kits)-23a enhances the expression of IKKalpha. The proliferation, migration, and invasion of EOC cells are increased by IKKalpha.
TLR signaling led to lower expression of LRRC14 (zeige LRRC14 ELISA Kits).
IKKalpha is an important determinant of poor outcome in patients with ER-positive invasive ductal breast cancer and thus may represent a potential therapeutic target
Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkalpha and Irf6 (zeige IRF6 ELISA Kits).
IKKalpha as a central mediator sensing both cytokine and microbial stimulation to suppress endoplasmic reticulum stress, thereby assuring antiinflammatory function during acute intestinal inflammation.
The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB (zeige NFKB1 ELISA Kits) by phosphorylating the regulatory molecule TAX1BP1 (zeige TAX1BP1 ELISA Kits).
Data indicate that the inflammation and proliferation-related functions of I kappa B kinase (IKKbeta (zeige IKBKB ELISA Kits)) can be uncoupled by quinoxaline urea analog 13-197.
Hematopoietic IKKalpha deficiency in mouse suppresses Akt (zeige AKT1 ELISA Kits) signaling, compromising monocyte/macrophage survival and this decreases early atherosclerosis.
Anatomy of a negative feedback loop: the case of IkappaBalpha (zeige NFKBIA ELISA Kits).
Epithelial-intrinsic IKK-alpha expression regulates group 3 innate lymphoid cell responses and antibacterial immunity.
IKKalpha mediated the repair of the kidney via infiltrated regulatory T (Treg) cells, which can produce anti-inflammatory cytokine IL10 (zeige IL10 ELISA Kits)
These findings reveal a molecular mechanism regulating migration and invasion of epithelial cells and establish a key direct link between IKKbeta (zeige IKBKB ELISA Kits) and cell motility controlled by Rap (zeige LRPAP1 ELISA Kits)-integrin signaling.
poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis
Ikk1 negatively regulates NF-kappaB (zeige NFKB1 ELISA Kits) by sequestering NEMO (zeige IKBKG ELISA Kits) from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB (zeige NFKB1 ELISA Kits).
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
, i kappa-B kinase alpha
, inhibitor of nuclear factor kappa-B kinase subunit alpha
, nuclear factor NF-kappa-B inhibitor kinase alpha
, SPFH domain-containing protein 1
, conserved helix-loop-helix ubiquitous kinase
, I-kappa-B kinase 1
, I-kappa-B kinase-alpha
, IKK-a kinase
, IkB kinase alpha subunit
, Nuclear factor NFkappaB inhibitor kinase alpha
, transcription factor 16
, I kappa B kinase 1
, I-kappa-B kinase alpha
, IKK alpha
, IkappaB kinase alpha
, ikappaB kinase
, IkB kinase-a