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Cdk2ap2 under normal conditions has a biphasic expression, suggesting regulatory roles in early-versus-late stem cell differentiation.
cyclin-dependent kinase 2-associated protein 1 (CDK2AP1 (zeige CDK2AP1 Proteine)), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 (zeige MBD3 Proteine) to the promoter region of Wnt (zeige WNT2 Proteine) signaling genes
Mouse DOC-1R gene can significantly inhibit cell growth and colony formation capacity.
identified a mitogen-activated protein kinase (zeige MAPK1 Proteine) partner, DOC1R, a murine homologue of a potential human tumor suppressor gene; characterized DOC1R during mouse oocyte meiosis resumption
Here, we introduce a transcriptional signature to specifically track CDK2 (zeige CDK2 Proteine) activity. It responds to genetic and chemical perturbations in the CDK (zeige CDK4 Proteine)-RB-E2F (zeige E2F1 Proteine) axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 (zeige CDK2 Proteine) activity during cell cycle progression
Here, we found that centrosomal protein of 76 kDa (Cep76 (zeige Cep76 Proteine)), previously shown to restrain centriole amplification, interacts with cyclin-dependent kinase 2 (CDK2 (zeige CDK2 Proteine)) and is a bona fide substrate of this kinase. Cep76 (zeige Cep76 Proteine) is preferentially phosphorylated by cyclin A (zeige CCNA2 Proteine)/CDK2 (zeige CDK2 Proteine) at a single site S83, and this event is crucial to suppress centriole amplification in S phase
The authors find that Spy1 (zeige SPDYA Proteine) confers structural changes to Cdk2 (zeige CDK2 Proteine) that obviate the requirement of Cdk (zeige CDK4 Proteine) activation loop phosphorylation.
CDK2 (zeige CDK2 Proteine) serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes
Date show that when Wee1 (zeige WEE1 Proteine) alone is inhibited, Chk1 (zeige CHEK1 Proteine) suppresses CDC45 (zeige CDC45 Proteine) loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (zeige CDK4 Proteine)-activity.
Results show that cyclin E1 (zeige CCNE1 Proteine) and CDK2 (zeige CDK2 Proteine) participate in STC1 (zeige STC1 Proteine) promoting cell proliferation of prostate neoplasm cells.
The data presented here suggest that the temporal separation of pro- and anti-apoptotic pathways by selective inhibition of CDK2 (zeige CDK2 Proteine) disrupts coherent signaling modules and may synergize with anti-proliferative drugs, averting toxic side effects from CDK1 (zeige CDK1 Proteine) inhibition.
periodic phosphorylation of Ku70 (zeige XRCC6 Proteine) by cyclin-cyclin (zeige PCNA Proteine) dependent kinases prevents the interaction of Ku with replication origin after initiation events in S-phase.
a SUMO-deficient Rb mutant results in reduced SUMOylation and phosphorylation, weakened CDK2 (zeige CDK2 Proteine) binding, and attenuated E2F-1 (zeige E2F1 Proteine) sequestration.
These two states are separated by different metastable states that share hybrid structural features with both forms of the kinase. In contrast, the CDK2/ANS complex landscape is compatible with a conformational selection picture where the binding of ANS in proximity of the alphaC helix causes a population shift toward the inactive conformation
This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene.
cyclin-dependent kinase 2-associated protein 2
, DOC-1 related protein
, DOC-1-related protein
, cdc2-related protein kinase
, cell devision kinase 2
, cell division protein kinase 2
, p33 protein kinase
, CDK2-associated protein 2
, tumor suppressor deleted in oral cancer related 1
, tumor suppressor deleted in oral cancer-related 1