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Collier, Fueger, Hohmeier, Newgard: Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines. in Diabetes 2006
Show all 5 Pubmed References
Mouse (Murine) AKT ELISA Kit für Sandwich ELISA - ABIN425439
Campo, Avenoso, DAscola, Scuruchi, Calatroni, Campo: Beta-arrestin 1 is involved in the catabolic response stimulated by hyaluronan degradation in mouse chondrocytes. in Cell and tissue research 2015
Human AKT ELISA Kit für Sandwich ELISA - ABIN625220
Sharma, Yang, Xi, Grotta, Aronowski, Savitz: IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways. in Brain research 2011
Human AKT ELISA Kit für Sandwich ELISA - ABIN625233
Wang, Rayes, Elahi, Lu, Hancock, Massie, Rowe, Aomari, Hossain, Durocher, Pinard, Tabariès, Siegel, Brodt: The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis. in Molecular cancer therapeutics 2015
Rat (Rattus) AKT ELISA Kit für Competition ELISA - ABIN772316
Waghe, Sarath, Gupta, Kandasamy, Choudhury, Kutty, Mishra, Sarkar: Arsenic causes aortic dysfunction and systemic hypertension in rats: Augmentation of angiotensin II signaling. in Chemico-biological interactions 2015
Rat (Rattus) AKT ELISA Kit für Sandwich ELISA - ABIN367995
Jain, Suryakumar, Prasad, Ganju: Differential activation of myocardial ER stress response: a possible role in hypoxic tolerance. in International journal of cardiology 2013
The metabolic defects of cycG (zeige CCNG1 ELISA Kits) mutant animals are abrogated by a concomitant loss of Wdb, CycG (zeige CCNG1 ELISA Kits) presumably influences Akt1 activity at the PP2A nexus; Well rounded (Wrd), another B' subunit of PP2A in Drosophila, binds CycG (zeige CCNG1 ELISA Kits) similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG (zeige CCNG1 ELISA Kits) mutants.
Our findings demonstrated that lovastatin restored LRRK2 (zeige LRRK2 ELISA Kits)-G2019S neurite degeneration by augmenting Akt/NRF2 (zeige NFE2L2 ELISA Kits) pathway and inhibiting downstream GSK3b (zeige GSK3b ELISA Kits) activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2 (zeige LRRK2 ELISA Kits)-G2019S parkinsonism.
subtle manipulation of foxo through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.
The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones
these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation
AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.
Akt1 governs two critical elements of synapse development, neurotransmitter receptor (zeige GRIN1 ELISA Kits) localization, and postsynaptic membrane elaboration
Tsc2 (zeige TSC2 ELISA Kits) mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 (zeige TSC2 ELISA Kits) mutants, leading to the hypothesis that Tsc2 (zeige TSC2 ELISA Kits) and Akt might work via the same genetic pathway to regulate synapse growth.
Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.
Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.
CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (zeige FNTA ELISA Kits), which further represses the activity of K(+) channel (zeige KCNC4 ELISA Kits) AKT1 in Arabidopsis.
Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.
AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.
These findings provide further insights into the signaling network consisting of CBL (zeige CBL ELISA Kits)-CIPK-PP2C interactions in the activation of the AKT1 channel.
Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.
AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.
In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.
CIPK23 directly phosphorylates the K+ transporter AKT1
Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (zeige CA2 ELISA Kits)+)-dependent manner, connecting the Ca(2 (zeige CA2 ELISA Kits)+) signal to K(+) uptake through activation of a K(+) channel (zeige KCNC4 ELISA Kits).
Tideglusib significantly reduced cerebral infarct volume at both 24h and 7days after HI injury. Tideglusib also increased phosphorylated GSK-3beta (zeige GSK3b ELISA Kits)(Ser9) and Akt(Ser473)
Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT/GSK3beta (zeige GSK3b ELISA Kits) signaling axis at cilia in SHH (zeige SHH ELISA Kits)-dependent medulloblastoma that is regulated by INPP5E (zeige INPP5E ELISA Kits) to maintain tumor cell cilia, promote SHH (zeige SHH ELISA Kits) signaling and thereby medulloblastoma progression.
mTORC2 (zeige CRTC2 ELISA Kits) complex is responsible for phosphorylating Akt at S(473).
FHL2 (zeige FHL2 ELISA Kits) facilitates ovarian granulosa cell tumor progression via controlling AKT1 transcription.
Omentin (zeige ITLN1 ELISA Kits) protects against lipopysaccharides-induced acute respiratory distress syndrome through suppressing pulmonary inflammation and promoti (zeige NOS3 ELISA Kits)ng endothelial barrier via an Akt/NOS3-dependent mechanism.
AIM2 (zeige AIM2 ELISA Kits) contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection.
Following transepithelial migration, neutrophils adhesion to ICAM-1 (zeige ICAM1 ELISA Kits) resulted in activation of Akt and beta-catenin (zeige CTNNB1 ELISA Kits) signaling, increased epithelial-cell proliferation, and wound healing.
Besides, both in vivo and in votro studies suggested that K145 stimulated insulin (zeige INS ELISA Kits) dependent Akt phosphorylation and subsequently activates FoxO1 (zeige FOXO1 ELISA Kits) phosphorylation therefore inhibited gluconeogenetic genes expression including PEPCK (zeige PEPCK ELISA Kits) and G6pase (zeige G6PC ELISA Kits). Our study figures out a potential extent increase the value of developing K145 as therapeutic candidate for diabetes.
C5a in vitro caused activation (phosphorylation) of MAPKs and Akt in cardiomyocytes, which required availability of both C5a receptors. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt in heart.
High Akt1 expression is associated with hepatocarcinogenesis.
ILT3 (zeige LILRB4 ELISA Kits) may functionally contribute to a regulatory network controlling tumor progression by suppressing the Akt pathway.
Extracellular polyamines induced proliferation and cancer cell migration by inducing ODC (zeige ODC1 ELISA Kits) and SSAT (zeige SAT1 ELISA Kits) expression, and the Akt1-mediated pathway.
The impact of AKT1 on glucocorticoid receptor (GR (zeige NR3C1 ELISA Kits))-induced transcriptional activity in cooperation with phospho-serine/threonine-binding protein 14-3-3 (zeige YWHAQ ELISA Kits), was examined.
These findings identify phospho-AKT in the primary tumor and miR (zeige MLXIP ELISA Kits)-200c later during tumor progression as prognostic molecules.
This study showed that the induction level of IL-32 (zeige IL32 ELISA Kits) was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS (zeige IRF6 ELISA Kits)-induced IL-32 (zeige IL32 ELISA Kits) expression in nasal polyp-derived fibroblasts was regulated via the TLR4 (zeige TLR4 ELISA Kits)/JNK (zeige MAPK8 ELISA Kits)/AKT/CREB (zeige CREB1 ELISA Kits) signaling pathway.
Phosphorylation of MITF (zeige MITF ELISA Kits) by AKT affects its downstream targets and causes TP53 (zeige TP53 ELISA Kits)-dependent cell senescence
IL-1beta (zeige IL1B ELISA Kits) induced apoptosis and the expression of catabolic mediators by inducing autophagy, and the autophagy in part was mediated through the activation of AKT/mTOR (zeige FRAP1 ELISA Kits)/P70S6K (zeige RPS6KB1 ELISA Kits) signaling pathway in human osteoarthritis chondrocytes.
KRAS mutations and AKT activation are present in Wilms tumors (WT) and may represent novel therapeutic targets for this tumor.
High AKT1 expression is associated with Lung cancer.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR (zeige FRAP1 ELISA Kits)-FOXO1 (zeige FOXO1 ELISA Kits) signaling and suppressing the activation of TLR4 (zeige TLR4 ELISA Kits) and/or NOD2 (zeige NOD2 ELISA Kits) signaling pathways.
Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.
In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.
Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
findings show that megalin (zeige LRP2 ELISA Kits) is the sensor that determines whether cells will be protected or injured by albumin (zeige ALB ELISA Kits); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [
protein kinase B (PKB/Akt)was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea
Akt signaling in porcine patellofemoral joint cartilage is dependent upon frequency of loading, cartilage zone, and the time interval between loading and cartilage harvest.
the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.
These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (zeige CTNNB1 ELISA Kits) accumulation and subsequent ovarian E2 production.
Caveolin-1 (zeige CAV1 ELISA Kits) scaffolding domain residue phenylalanine 92 modulates Akt signaling
TG2 (zeige TGM2 ELISA Kits) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta (zeige GSK3b ELISA Kits), and NF-kappaB (zeige NFKB1 ELISA Kits).
The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (zeige NOX1 ELISA Kits), reactive oxygen species, and PI3-kinase (zeige PIK3CA ELISA Kits) in stimulated NO release.
PI3K/Akt and p53 (zeige TP53 ELISA Kits) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide
Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR (zeige FRAP1 ELISA Kits), p70S6K (zeige RPS6KB1 ELISA Kits), and ERK1/2 (zeige MAPK1/3 ELISA Kits).
Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (zeige NOS3 ELISA Kits) activation in endothelial cells
Losartan metabolite stimulates eNOS (zeige NOS3 ELISA Kits) phosphorylation and suppresses tumor necrosis factor alpha (zeige TNF ELISA Kits)-induced endothelial cell apoptosis by activating AKT1.
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
, RAC-alpha serine/threonine-protein kinase
, protein kinase B alpha
, proto-oncogene c-Akt
, rac protein kinase alpha
, AKT1 kinase
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, actin, cytoplasmic 1
, Akt kinase
, dAkt kinase
, protein kinase B
, related to PKA to PKC protein kinases
, related to the A and C kinases
, 5C actin
, actin 5 C
, actin 5C
, actin 5c
, actin A1
, cellular cytoskeletal beta-actin
, gamma non-muscle actin
, beta actin
, RAC protein kinase alpha RAC-PK alpha
, murine thymoma viral (v-akt) oncogene homolog 1
, thymoma viral proto-oncogene 1
, v-akt murine thymoma viral oncogene-like protein 1
, serine/threonine protein kinase
, protein kinase Akt-1
, protein kinase B, alpha
, v-akt murine thymoma viral oncogene homolog 1
, v-akt murine thymoma viral oncogene-like 1