This is a synthetic peptide designed for use in combination with anti-VHL Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: HRCA1, RCA1, VHL1, pVHL
Protein Interaction Partner: EPAS1,FLNA,FN1,HIF1A,HIF1A,PHF17,USP33,VBP1,CCT3,CUL2,EPAS1,FLNA,FN1,HIF1A,HIF1AN,HIF3A,HNRNPA2B1,PHF17,POLR2G,PSMC3,RBX1,RNF139,SP1,TCEB1,TCEB2,USP33,VBP1,ZNF197,APRT,ATM,ATXN2,CAB39,CCDC59,CCDC82,CCT3,CDK2,CDO1,CHMP2B,CNTF,CSTB,CSTF3,CUL2,CUL5,CYBA,DGKZ