Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
Produktmerkmale
This is a synthetic peptide designed for use in combination with anti-RUNX1T1 antibody (Catalog #: ARP58127_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
Alias Symbols: AML1T1, CBFA2T1, CDR, ETO, MGC2796, MTG8, MTG8b, ZMYND2
Protein Interaction Partner: CBFA2T2,HDAC1,HDAC3,NCOR1,SIN3A,TCF12,TCF12,TCF3,TCF4,ABI3,ATN1,BCL6,C19orf57,CBFA2T3,GFI1,HDAC1,HDAC3,HDAC8,HSP90AA1,ID1,ID3,KPNA1,KPNB1,NCOR1,NCOR2,NECAB2,PRKAR2A,RUNX1T1,SIN3A,TAF9B,TCF3,TCF4,UBQLN4,WBP11,ZBTB16,ABI3,C19orf57,CBFA2T2,CBFA2T3,CEP170L,GFI1,HDAC1,HDAC2,HDAC3,HDAC8,KPNA1,KPNB1,NCOR1,NCOR2,NECAB2,OTUD4,PRKAR2A,RUNX1T1,SIN3A,TAF9B,THRAP3,VDR,WBP11,ZBTB16