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Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (Middle Region) Peptid

NCF4 Reaktivität: Human Wirt: Synthetic BP, WB
Produktnummer ABIN980523
  • Target Alle NCF4 Produkte
    NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
    Protein Region
    Middle Region
    Spezies
    Human
    Quelle
    • 8
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-NCF4 antibody (Catalog #: ARP46010_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
    Synonyme
    p40phox Peptide, AI451400 Peptide, NCF Peptide, P40PHOX Peptide, SH3PXD4 Peptide, neutrophil cytosolic factor 4 Peptide, ncf4 Peptide, Ncf4 Peptide, NCF4 Peptide
    Hintergrund
    NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

    Alias Symbols: MGC3810, NCF, P40PHOX, SH3PXD4

    Protein Interaction Partner: CORO1A,CYBA,CYBB,MSN,NCF1,NCF2,PRKCD,TXN,XRCC6,MSN,NCF1,NCF2,PRKDC,TXN,XRCC6

    Protein Size: 348
    Molekulargewicht
    39 kDa
    Gen-ID
    4689
    NCBI Accession
    NM_013416, NP_038202
    UniProt
    A8K4F9
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