Major Vault Protein (MVP) (N-Term) Peptid
MVP
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle MVP Produkte
- MVP (Major Vault Protein (MVP))
- Protein Region
- N-Term
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-MVP antibody (Catalog #: ARP58642_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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-
- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MVP (Major Vault Protein (MVP))
- Synonyme
- LRP Peptide, VAULT1 Peptide, 2310009M24Rik Peptide, cb771 Peptide, wu:fb52b05 Peptide, wu:fc02g01 Peptide, mvp Peptide, MGC145641 Peptide, Tb05.45E22.810 Peptide, major vault protein Peptide, major vault protein L homeolog Peptide, putative major vault protein Peptide, MVP Peptide, Mvp Peptide, mvp Peptide, mvp.L Peptide, Tc00.1047053510353.10 Peptide, Tb927.5.4460 Peptide, Tb10.70.0520 Peptide, Tb10.70.5840 Peptide, LMJF_05_0060 Peptide
- Hintergrund
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MVP is required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. MVP down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. MVP down-regulates SRC activity and signaling through MAP kinases.This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences, however, the open reading frames are the same in both transcripts.
Alias Symbols: LRP, VAULT1
Protein Interaction Partner: YBX1,ESR1,PARP4,PTEN,PTPN11,SLC2A4,ESR1,PARP4,PTEN
Protein Size: 893 - Molekulargewicht
- 98 kDa
- Gen-ID
- 9961
- NCBI Accession
- NM_005115, NP_005106
- UniProt
- Q14764
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