MutL Homolog 1 (MLH1) (N-Term) Peptid
MLH1
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle MLH1 Produkte
- MLH1 (MutL Homolog 1 (MLH1))
- Protein Region
- N-Term
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-MLH1 antibody (Catalog #: ARP56076_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MLH1 (MutL Homolog 1 (MLH1))
- Synonyme
- CG11482 Peptide, Dmel\\CG11482 Peptide, dmlh-1 Peptide, dmlh1 Peptide, zgc:66301 Peptide, MLH1 Peptide, LOC100232198 Peptide, 1110035C23Rik Peptide, AI317206 Peptide, AI325952 Peptide, AI561766 Peptide, COCA2 Peptide, FCC2 Peptide, HNPCC Peptide, HNPCC2 Peptide, hMLH1 Peptide, mutL homolog 1 Peptide, CG11482 gene product from transcript CG11482-RB Peptide, mutL homolog 1 S homeolog Peptide, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) Peptide, DNA mismatch repair protein Mlh1 Peptide, MLH1 Peptide, Mlh1 Peptide, mlh1.S Peptide, mlh1 Peptide, LOC588545 Peptide
- Hintergrund
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This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC.This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: COCA2, FCC2, HNPCC, HNPCC2, MGC5172, hMLH1
Protein Interaction Partner: E2F1,E2F4,BLM,EXO1,EXO1,MBD4,MLH3,MSH4,MYC,PMS1,PMS2,AP2B1,BLM,BRCA1,CASP3,EXO1,FRMD6,MBD4,MLH3,MSH4,MYC,PMS1,PMS2,RAD9A,TRIM29,UBOX5,ZC3H11A,AIFM1,AMOT,AP2B1,ATAD3A,ATAD3B,ATM,ATP5A1,BLM,BRCA1,BRIP1,DOCK7,EXO1,EXO1,FRMD6,KPNA2,KPNB1,MBD4,MLH3,MRE11A,MSH2,MSH3,MSH4,MSH6,MTMR15,MYC,NBN,NTG2,PIK3C2A,PMS1,PMS2,PPP2R1A,PPP2R2A,PPP2R2B,PPP2R2D,PPP3CB,PPP3CC,PRKDC,PSD3,PYGB,RAD50,RFC1,RUVBL1,RUVBL2,SGS1,SMC1A,TRIM29,UBAP2L,UBC,UBOX5,WDR61,XRN1,YLPM1,ZC3H11A
Protein Size: 756 - Molekulargewicht
- 84 kDa
- Gen-ID
- 4292
- NCBI Accession
- NM_000249, NP_000240
- UniProt
- P40692
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