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Hyaluronan Synthase 1 (HAS1) (N-Term) Peptid

HAS1 Reaktivität: Human Wirt: Synthetic BP, WB
Produktnummer ABIN977857
  • Target Alle HAS1 Produkte
    HAS1 (Hyaluronan Synthase 1 (HAS1))
    Protein Region
    N-Term
    Spezies
    Human
    Quelle
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Sequenz
    EPAAAGAVGA GAYREVEAED PGRLAVEALV RTRRCVCVAQ RWGGKREVMY
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-HAS1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    HAS1 (Hyaluronan Synthase 1 (HAS1))
    Synonyme
    dg42 Peptide, Xhas1 Peptide, HAS Peptide, shas1 Peptide, hyaluronan synthase 1 Peptide, hyaluronan synthase 1 S homeolog Peptide, has1 Peptide, HAS1 Peptide, Has1 Peptide, has1.S Peptide
    Hintergrund
    Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis.

    Alias Symbols: HAS

    Protein Interaction Partner: EIF6,VHL

    Protein Size: 578
    Molekulargewicht
    64 kDa
    Gen-ID
    3036
    NCBI Accession
    NM_001523, NP_001514
    UniProt
    Q92839
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