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Dickkopf 2 Homolog (DKK2) (Middle Region) Peptid

DKK2 Reaktivität: Maus Wirt: Synthetic BP, WB
Produktnummer ABIN975816
  • Target Alle DKK2 Produkte
    DKK2 (Dickkopf 2 Homolog (DKK2))
    Protein Region
    Middle Region
    Spezies
    Maus
    Quelle
    • 3
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Sequenz
    NGICIPVTES ILTPHIPALD GTRHRDRNHG HYSNHDLGWQ NLGRPHSKMP
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-Dkk2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    DKK2 (Dickkopf 2 Homolog (DKK2))
    Synonyme
    DKK-2 Peptide, Dkk4 Peptide, zgc:171574 Peptide, dickkopf WNT signaling pathway inhibitor 2 Peptide, DKK2 Peptide, Dkk2 Peptide, dkk2 Peptide
    Hintergrund
    Dkk2 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer's disease.

    Alias Symbols: -

    Protein Size: 259
    Molekulargewicht
    28 kDa
    Gen-ID
    56811
    NCBI Accession
    NM_020265, NP_064661
    UniProt
    Q9QYZ8
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