Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) Peptid
CYP2D6
Reaktivität: Human
Wirt: Synthetic
BP, WB, IHC
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- Target Alle CYP2D6 Produkte
- CYP2D6 (Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6))
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-CYP2D6 antibody (Catalog #: ARP41675_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CYP2D6 (Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6))
- Synonyme
- CPD6 Peptide, CYP2D Peptide, CYP2D7AP Peptide, CYP2D7BP Peptide, CYP2D7P2 Peptide, CYP2D8P2 Peptide, CYP2DL1 Peptide, CYPIID6 Peptide, P450-DB1 Peptide, P450C2D Peptide, P450DB1 Peptide, CYP2D42 Peptide, MGC64445 Peptide, cyp2d2 Peptide, cyp2d6-a Peptide, CYP2D6 Peptide, cytochrome P450 family 2 subfamily D member 6 Peptide, cytochrome P450, family 2, subfamily D, polypeptide 6 Peptide, cytochrome 2D6 Peptide, cytochrome P450 family 2 subfamily D member 6 S homeolog Peptide, cytochrome P450 2D6 Peptide, cytochrome P450 2D6-like Peptide, CYP2D6 Peptide, cyp2d6-b Peptide, cyp2d6.S Peptide, cyp2d6 Peptide, LOC100988273 Peptide
- Hintergrund
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CYP2D6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20 % of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug, sparteine and propafenone, both anti-arrythmic drugs, and amitryptiline, an anti-depressant.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20 % of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug, sparteine and propafenone, both anti-arrythmic drugs, and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population, certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: RP4-669P10.2, CPD6, CYP2D, CYP2D@, CYP2DL1, MGC120389, MGC120390, P450-DB1, P450C2D, CYPIID6, P450DB1, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2
Protein Size: 497 - Molekulargewicht
- 55 kDa
- Gen-ID
- 1565
- NCBI Accession
- NM_000106, NP_000097
- UniProt
- P10635
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