Cytokine Inducible SH2-Containing Protein (CISH) (N-Term) Peptid
CISH
Reaktivität: Maus
Wirt: Synthetic
BP, WB
-
- Target Alle CISH Produkte
- CISH (Cytokine Inducible SH2-Containing Protein (CISH))
- Protein Region
- N-Term
- Spezies
- Maus
-
Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- RESGWYWGSI TASEARQHLQ KMPEGTFLVR DSTHPSYLFT LSVKTTRGPT
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-Cish Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
-
-
- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- CISH (Cytokine Inducible SH2-Containing Protein (CISH))
- Synonyme
- CISH Peptide, cis Peptide, cish.a Peptide, ptk9l Peptide, twf1l Peptide, wu:fk57g04 Peptide, zgc:154062 Peptide, zgc:91817 Peptide, g18 Peptide, socs Peptide, cis-1 Peptide, cish Peptide, BACTS2 Peptide, CIS Peptide, CIS-1 Peptide, G18 Peptide, SOCS Peptide, AI385595 Peptide, CIS1 Peptide, Cis Peptide, F17 Peptide, F23 Peptide, cytokine inducible SH2 containing protein Peptide, cytokine inducible SH2-containing protein Peptide, CISH Peptide, cish Peptide, Cish Peptide
- Hintergrund
-
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: AI385595, CIS1, Cis, F17, F23
Protein Interaction Partner: Stat5a
Protein Size: 257 - Molekulargewicht
- 28 kDa
- Gen-ID
- 12700
- NCBI Accession
- NM_009895, NP_034025
- UniProt
- Q62225
-
Sie sind hier:
