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beta-Transducin Repeat Containing (BTRC) (C-Term) Peptid

BTRC Reaktivität: Maus Wirt: Synthetic BP, WB
Produktnummer ABIN973943
  • Target Alle BTRC Produkte
    BTRC (beta-Transducin Repeat Containing (BTRC))
    Protein Region
    C-Term
    Spezies
    Maus
    Quelle
    • 1
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Sequenz
    LVEHSGRVFR LQFDEFQIVS SSHDDTILIW DFLNDPAAHA EPPRSPSRTY
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-Btrc Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    BTRC (beta-Transducin Repeat Containing (BTRC))
    Synonyme
    BTRC Peptide, Beta-TrCP Peptide, betaTrCP Peptide, btrcp Peptide, btrcp1 Peptide, fbw1a Peptide, fbxw1 Peptide, fbxw1a Peptide, fwd1 Peptide, btrc Peptide, beta-TrCP Peptide, BETA-TRCP Peptide, FBW1A Peptide, FBXW1 Peptide, FBXW1A Peptide, FWD1 Peptide, bTrCP Peptide, bTrCP1 Peptide, beta-TrCP1 Peptide, btrc-a Peptide, Beta-Trcp1 Peptide, Fbw1a Peptide, HOS Peptide, Slimb Peptide, b-TrCP Peptide, mKIAA4123 Peptide, beta-transducin repeat containing E3 ubiquitin protein ligase Peptide, beta-transducin repeat containing Peptide, beta-TrCP Peptide, beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog Peptide, beta-transducin repeat containing protein Peptide, BTRC Peptide, btrc Peptide, LOC100634006 Peptide, Btrc Peptide, btrc.S Peptide
    Hintergrund
    Btrc is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1.

    Alias Symbols: Beta-Trcp1, FWD1, Fbw1a, KIAA4123, Slimb, b-TrCP, beta-TrCP, mKIAA4123, HOS

    Protein Size: 605
    Molekulargewicht
    69 kDa
    Gen-ID
    12234
    NCBI Accession
    NM_001037758, NP_001032847
    UniProt
    Q3ULA2
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