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Aurora Kinase A (AURKA) (N-Term), (Ser89) Peptid

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Proteinname
Protein Region
N-Term, Ser89
Quelle
Synthetic
Protein-Typ Synthetic
Applikation
Blocking Peptide (BP)
Pubmed 5 Publikationen vorhanden
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Menge 0.1 mg
Optionen
Lieferung nach Deutschland ( )
Verfügbarkeit
Immunogen Synthetic peptide
Spezifität The synthetic peptide sequence used to generate the antibody AP7002b was selected from the N-term region of human Aurora-A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Hintergrund Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Auroria kinase A may play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. It may be involved in microtubule formation and/or stabilization. This protein has also been postulated to play a key role during tumor development and progression. Aurora kinase A localizes on centrosomes in interphase cells and at each spindle pole in mitosis. It is highly expressed in testis, weakly in skeletal muscle, thymus and spleen, and also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly afterward. Defects in Aurora kinase A are responsible for numerical centrosome aberrations including aneuploidy.
Beschränkungen Nur für Forschungszwecke einsetzbar
Lagerung 4
Informationen zur Lagerung Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Haltbarkeit 6 months
Allgemeine Veröffentlichungen Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Tanaka, Ueda, Kanamori et al.: "Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1." in: The Journal of biological chemistry, Vol. 277, Issue 12, pp. 10719-26, 2002 (PubMed).

Deloukas, Matthews, Ashurst et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, 2002 (PubMed).

Nigg: "Mitotic kinases as regulators of cell division and its checkpoints." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 1, pp. 21-32, 2001 (PubMed).

Shindo, Nakano, Kuroyanagi et al.: "cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2." in: Biochemical and biophysical research communications, Vol. 244, Issue 1, pp. 285-92, 1998 (PubMed).

Produktnummer ABIN696474

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