Unc-51 Like Kinase 1 (C. Elegans) (ULK1) (N-Term) Peptid

Details zu Produkt Nr. ABIN2184424, Anbieter: Anmelden zum Anzeigen
Proteinname
  • ULK1
  • si:dkey-11o18.7
  • ulk1
  • ATG1
  • ATG1A
  • UNC51
  • Unc51.1
  • hATG1
  • AU041434
  • mKIAA0722
  • unc-51-like kinase 1 (C. elegans)
  • unc-51-like kinase 1b (C. elegans)
  • unc-51 like autophagy activating kinase 1
  • unc-51 like kinase 1
  • ULK1
  • ulk1b
  • Ulk1
Protein Region
N-Term
Spezies
Human
3
1
1
1
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Geblockter Antikörper anti-ULK1 Antikörper (Unc-51 Like Kinase 1 (C. Elegans)) (N-Term) (ABIN2785618)
Sequenz PEVIMSQHYD GKADLWSIGT IVYQCLTGKA PFQASSPQDL RLFYEKNKTL
Produktmerkmale This is a synthetic peptide designed for use in combination with anti-ULK1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Reinigung Purified
Hintergrund ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation.

Alias Symbols: ATG1, ATG1A, UNC51, Unc51.1, hATG1

Protein Size: 1050
Molekulargewicht 112 kDa
Gen-ID 8408
NCBI Accession NM_003565, NP_003556
UniProt O75385
Forschungsgebiet Cardiovascular, Autophagy
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handhabung Avoid repeat freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.