Bone Morphogenetic Protein 10 (BMP10) (C-Term) Peptid
BMP10
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle BMP10 Produkte
- BMP10 (Bone Morphogenetic Protein 10 (BMP10))
- Protein Region
- C-Term
- Spezies
- Human
-
Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- GYEAYECRGV CNYPLAEHLT PTKHAIIQAL VHLKNSQKAS KACCVPTKLE
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-BMP10 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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-
- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeat freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- BMP10 (Bone Morphogenetic Protein 10 (BMP10))
- Synonyme
- BMP10 Peptide, si:dkey-13n15.5 Peptide, Bmp10 Peptide, BMP9 Peptide, BMP-10 Peptide, bone morphogenetic protein 10 Peptide, BMP10 Peptide, bmp10 Peptide, LOC662386 Peptide, Bmp10 Peptide
- Hintergrund
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BMP10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.
Alias Symbols: -
Protein Size: 424 - Molekulargewicht
- 46 kDa
- Gen-ID
- 27302
- NCBI Accession
- NM_014482, NP_055297
- UniProt
- O95393
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