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findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (zeige NCS1 ELISA Kits) in mitochondrial function via its association with several mitochondrial proteins.
These observations provide evidence that the synaptobrevin-2 transmembrane domain catalyzes the membrane fusion process by its structural flexibility, actively setting the pace of fusion pore expansion.
Syp1 (zeige SYP ELISA Kits) clears Syb2 from the presynaptic active zone to prevent short-term depression.
The balance between synaptophysin (zeige SYP ELISA Kits) and sybII levels is critical for the correct targeting of sybII to synaptic vesicles and suggests that alterations in synaptophysin (zeige SYP ELISA Kits) levels might affect the localisation of sybII and subsequent presynaptic performance.
Thus, lipid-anchored syb2 provides little or no support for exocytosis, and anchoring syb2 to a membrane by a TMD (zeige TTN ELISA Kits) greatly improves its function
Vamp2 mutations impair the ability of Munc18-1 (zeige STXBP1 ELISA Kits) to promote trans-SNARE (zeige VTI1B ELISA Kits) zippering. These mutations inhibit spontaneous as well as evoked neurotransmitter release, providing evidence for the Vamp2-regulating function of Munc18-1 (zeige STXBP1 ELISA Kits) in synaptic exocytosis.
These results provide a novel molecular mechanism for autocrine negative feedback regulation of insulin (zeige INS ELISA Kits) secretion.
Results suggest that side chains in the syb2 transmembrane domain influence the kinetics of exocytosis by perturbing the packing of the surrounding lipids
we demonstrate that Syb2 and SNAP25 (zeige SNAP25 ELISA Kits) mediate the vesicular release of BDNF (zeige BDNF ELISA Kits) in axons and dendrites of cortical neurons
Here we report on transgenic mice expressing a ubiquitinated synaptic vesicle protein (Ub(G76V)-GFP-Syb2) that develop progressive degeneration of motor nerve terminals.
VAMP2 is the major v-SNARE (zeige GOSR1 ELISA Kits) involved in GLUT4 (zeige SLC2A4 ELISA Kits) trafficking to the surface of 3T3-L1 adipocytes.
Data suggest that A-syn (zeige FYN ELISA Kits) (alpha-synuclein) promotes SNARE (zeige NAPA ELISA Kits)-dependent vesicle docking; phosphatidylserine (PS) removal from t-SNARE (zeige NAPA ELISA Kits)-bearing vesicles causes A-syn (zeige FYN ELISA Kits) to inhibit vesicle docking; PS removal from v-SNARE (zeige VTI1B ELISA Kits)-bearing vesicles promotes vesicle docking; the C-terminal 45 residues of A-syn (zeige FYN ELISA Kits) are required for promotion of vesicle docking. (Here, t-SNARE (zeige NAPA ELISA Kits) is SNAP-25 (zeige SNAP25 ELISA Kits); v-SNARE (zeige VTI1B ELISA Kits) is VAMP2.)
A significant interactive two-locus model of STX1A_rs4363087|VAMP2_rs2278637 (presynaptic genes) was observed among SVC (zeige COL4A1 ELISA Kits) variants in all epilepsy cases.
VAMP2 is a promising new plasma cell marker
VAMP2 is involved in Porphyromonas gingivalis recycling pathway.VAMP2 is localized in early endosomes in gingival epithelial cells.
The present study addressed for the first time the unique substrate recognition mechanism of LC/F5 substrate cleavage of VAMP-2 by Botulinum Neurotoxin subtype F5.
This study showed that decreased Levels of VAMP2 correlate with Duration of Dementia.
VAMP2-NRG1 (zeige NRG1 ELISA Kits) is a novel oncogenic fusion gene representing a new addition to the list of NRG1 (zeige NRG1 ELISA Kits) fusion genes, which together may form an important diagnostic and clinical category of lung adenocarcinoma cases
A large vesicular pool of VAMP2 maintained by AP180 (zeige SNAP91 ELISA Kits) is crucial to sustain efficient neurotransmission.
SNARE (zeige NAPA ELISA Kits) complex genes and their interactions may play a significant role in susceptibility and working memory of ADHD.
miR (zeige MLXIP ELISA Kits)-206 regulates lung surfactant secretion by limiting the availability of VAMP-2 protein.
VAMP-2 is critical to lysosome fusion in membrane raft clustering, and this VAMP-2-mediated lysosome-MR signalosomes contribute to redox regulation of coronary endothelial function.
VAMP2 is restricted from forming the SNARE (zeige NAPA ELISA Kits) (soluble N-ethylmaleimide-sensitive fusion protein (zeige NSF ELISA Kits) attachment protein receptor) complex in chromaffin granules from adrenal medullae to the same degree as in brain-purified synaptic vesicles.
Lengthening juxtamembrane region of synaptobrevin-2 severely reduced occurrence of rapid single events, leaving slow ones unchanged. It also impaired increase in fast-fusion mode that normally follows elevation of intracellular Ca2 (zeige CA2 ELISA Kits)+ levels.
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
vesicle-associated membrane protein 2 (synaptobrevin 2)
, synaptobrevin II
, vesicle-associated membrane 2
, Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2)
, Vesicle-associated membrane protein (synaptobrevin 2)
, synaptobrevin 2
, vesicle associated membrane protein 2
, vesicle-associated membrane protein 2