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RAB27A, RAB27B (zeige RAB27B ELISA Kits) and VPS36 (zeige VPS36 ELISA Kits) are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B (zeige RAB27B ELISA Kits) and VPS36 (zeige VPS36 ELISA Kits), with RAB27A and RAB27B (zeige RAB27B ELISA Kits) being dependent on VPS36 (zeige VPS36 ELISA Kits).
identified small molecule inhibitors of Rab27a-JFC1 binding that were also active in cell-based neutrophil-specific exocytosis assays, demonstrating the druggability of Rab (zeige HRB ELISA Kits) GTPases and their effectors.
MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.
decreased expression of Rab27A and Rab27B (zeige RAB27B ELISA Kits), especially Rab27A, closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.
We report two unrelated teenagers with hemophagocytic lymphohistiocytosis and an identical heterozygous RAB27A mutation (c.259G-->C).
Data suggest that microRNA miR (zeige MLXIP ELISA Kits)-582-5p may function as a tumor suppressor in the development of colorectal carcinoma (CRC (zeige CALR ELISA Kits)) by targeting RAS-related GTP-binding protein (zeige RAB10 ELISA Kits) (Rab27a), indicating a novel therapeutic strategy for patients with CRC (zeige CALR ELISA Kits).
Experimental data are reviewed with a focus on the secretory Rab27 family of small GTPases and their implications in cancer progression.
miR (zeige MLXIP ELISA Kits)-122 has a Rab27a-dependent function in the hepatitis C virus lifecycle
Rab27A may be used as a valuable prognostic biomarker for colorectal carcinoma patients.
Our data indicate that RAB27A expression is an independent prognostic marker for pancreatic ductal adenocarcinoma
Rab27a is a possible target for intervention in inflammatory processes in which GM-CSF (zeige CSF2 ELISA Kits)-dependent neutrophil priming is involved.
These results suggest that the dual effector, Noc2 (zeige RPH3AL ELISA Kits), regulates the transition from Rab2a (zeige RAB2A ELISA Kits)-mediated granule biogenesis to Rab27a-mediated granule exocytosis.
Loss of Rab3D (zeige RAB3D ELISA Kits) from secretory vesicles, leading to disproportionate Rab27-to-Rab3D (zeige RAB3D ELISA Kits) activity, may contribute to the enhanced release of cathepsin S (zeige CTSS ELISA Kits) in tears of patients with Sjogren's syndrome.
The Rab27A regulates CG exocytosis following MII-stage oocyte activation.
Given that GTP (zeige AK3 ELISA Kits)- and GDP-bound Rab27a regulate exocytosis.
This paper showed an inhibitory effect of Rab27a directly at the pore forming CaV1.3 (zeige CACNA1D ELISA Kits) subunit of L-type channels, leading to decreased current density and reduced VEGF-A (zeige VEGFA ELISA Kits) secretion by the retinal pigment epithelium.
results show that Rab27A is present in mouse pancreatic acinar cells and mainly regulates secretion through the minor-regulated pathway
Rab27A deficiency shows the increased surface level of c-fms (zeige CSF1R ELISA Kits), and the delayed downregulation of RANK in ashen cells, resulting in enhanced signaling of M-CSF (zeige CSF1R ELISA Kits) and RANKL (zeige TNFSF11 ELISA Kits).
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
RAB27A, member RAS oncogene family
, Ras-related protein Rab-27A
, rab27a, member ras oncogene family
, ras-related protein Rab-27A
, GTP-binding protein Ram
, member RAS oncogene family, RAB27A
, low Mr GTP-binding protein
, ram p25
, RAS oncogene family member