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We identified interactions between RalA (zeige rala ELISA Kits) and its effectors sec5 (zeige EXOC2 ELISA Kits) and exo84 in the Exocyst complex as directly necessary for migration and invasion of prostate cancer tumor cells.
shRNA-mediated knockdown of the Ral effector proteins Sec5 and Exo84, but less so in the case of RalBP1, reduced oncogenic RalGEF-mediated transformation and oncogenic Ras-driven tumorigenic growth of human cells.
evidence that mammalian exocyst components are present as distinct subcomplexes on vesicles and the plasma membrane and that Ral (zeige rala ELISA Kits) GTPases regulate the assembly interface of a full octameric exocyst complex through interaction with Sec5 (zeige EXOC2 ELISA Kits) and Exo84
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
exocyst complex component 8
, exocyst complex 84-kDa subunit
, Exocyst complex component 8
, exocyst complex 84 kDa subunit
, putative protein, with a coiled coil domain, of eukaryotic origin (77.8 kD) (1P228)