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Tbx2 mediates BMP signal to down-regulate FGF signaling pathway by repressing Flrt3 (zeige FLRT3 ELISA Kits) expression for anterior tissue formation.
Results suggest that the negative regulatory loops between BMP/Tbx2 and Gremlin (zeige GREM1 ELISA Kits) or Hey1 (zeige HEY1 ELISA Kits) are responsible for defining the territory of the pronephric nephron.
Bone morphogenetic protein signaling regulates hepatoblast-like cell differentiation into hepatocytes through tbx2b.
propose here a rather unique role of Med10 (zeige MED10 ELISA Kits) in orchestrating cardiac valve formation by mediating Foxn4 (zeige FOXN4 ELISA Kits) dependent tbx2b transcription, expression of Has2 (zeige HAS2 ELISA Kits) and subsequently proper development of the cardiac jelly
This work establishes a novel link between tbx2b and gdf6a in determining photoreceptor fates.
CNBP (zeige CNBP ELISA Kits) up-regulates tbx2b and smarca5, and down-regulates wnt5b (zeige WNT5B ELISA Kits) gene expression.
Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling is both sufficient and required for the induction of BMP4 (zeige BMP4 ELISA Kits) and Tbx2b expression in the AVC
In zebrafish, two tbx2 genes are functionally redundant for regulating chamber development, while each gene is required independently for development of the atrioventricular canal.
results uncover an evolutionarily conserved role of Tbx2/3 transcription factors during remodeling of the heart myocardium and highlight the importance of controlling cell proliferation as a driving force of morphogenesis
Flh and Tbx2b regulate separate programs of pineal and parapineal development
TBX-2 functions as an UNC-37 dependent transcriptional repressor
Reduction of SUMOylation enhances the effect of a tbx-2 hypomorphic mutant on embryonic viability and pharyngeal muscle development, and that repression of a downstream target of TBX-2 depends on SUMOylation.
These results identify NF-Y as an important regulator of tbx-2 function in vivo.
Ce-TBX-2, the TBX2/TBX3 (zeige TBX3 ELISA Kits) transcriptional factor homologue of the nematode Caenorhabditis elegans, is involved in olfactory adaptation
TBX-2 and SUMO-conjugating enzymes are necessary for ABa-derived pharyngeal muscle, and we hypothesize that TBX-2 function requires sumoylation.
The analysis suggests that a positive feedback loop between tbx-2 and pha-4 is required for blastomere-derived precursors to commit to pharyngeal muscle fate.
In screens for mutants with abnormal HSN (zeige FSCN1 ELISA Kits) motor neuron development, we identified the T-box protein TBX-2 as being important for both HSN (zeige FSCN1 ELISA Kits) and PHB (zeige PHB ELISA Kits) sensory neuron differentiation.
TBX2 is a central component of the PTEN/PI3K (zeige PIK3CA ELISA Kits)/AKT (zeige AKT1 ELISA Kits) signaling pathway deregulation in RMS cells and that targeting TBX2 in RMS tumors may offer a novel therapeutic approach for RMS
this new molecular-grade based on the combination of TBX2 and TBX3 (zeige TBX3 ELISA Kits) methylation is an excellent marker for predicting progression to muscle-invasive bladder cancer in patients with primary pTaG1/2 bladder cancer.
Our results suggest a conserved role of Tbx2-related proteins in cell invasion and metastasis-related processes
Data show that the down-regulation of T-box transcription factor TBX2 by transforming growth factor beta I (TGF-beta1 (zeige TGFB1 ELISA Kits)) is mediated by T-box transcription factor TBX3 (zeige TBX3 ELISA Kits).
The data suggested that the DNA sequence variants within the TBX2 gene promoter was implicated in the indirect inguinal hernia development as a rare cause.
High TBX2 expression is associated with breast cancer.
High TBX2 expression is associated with non-small cell lung cancer.
TBX2 was a significantly prognostic factor for decreased survival.
deregulated TBX2 serves as an oncogene (zeige RAB1A ELISA Kits) in rhabdomyosarcoma
Knocking down TBX2 sensitises the cells to cisplatin by disrupting the ATM (zeige ATM ELISA Kits)-CHK2 (zeige CHEK2 ELISA Kits)-p53 (zeige TP53 ELISA Kits) signalling pathway.
Tbx18 (zeige TBX18 ELISA Kits) does not function redundantly with Tbx2 or Tbx20 (zeige TBX20 ELISA Kits) in epicardial development.
Tbx2 and Tbx3 (zeige TBX3 ELISA Kits) function downstream of Shh (zeige SHH ELISA Kits) to maintain pro-proliferative mesenchymal Wnt (zeige WNT2 ELISA Kits) signaling.
Standard chromatin immunoprecipitation and reporter assays suggest that TBX2 represses Oca2 at least in part directly. Hence, the results suggest that TBX2 may act as a nexus linking cell proliferation and melanogenesis
Msx1 (zeige MSX1 ELISA Kits) and Tbx2 antagonistically regulate Bmp4 (zeige BMP4 ELISA Kits) expression during the bud-to-cap stage transition in tooth development.
formation of the neurohypophysis requires Tbx3 (zeige TBX3 ELISA Kits) and Tbx2 to sequester the SRY box-containing transcription factor Sox2 (zeige SOX2 ELISA Kits) away from a Shh (zeige SHH ELISA Kits) forebrain enhancer (SBE2)
We show that Tbx2 directly represses Grem1 in distal regions of the posterior limb mesenchyme allowing Bone morphogenetic protein (Bmp) signaling to abrogate Fgf4/9/17 expression in the overlying epithelium.
The identification of TBX2 as a target for PAX3 (zeige PAX3 ELISA Kits) provides a key insight into how PAX3 (zeige PAX3 ELISA Kits) may contribute to melanoma evolution.
Tbx2-mediated regulation of Cdkn1a (zeige CDKN1A ELISA Kits) and Cdkn1b (zeige CDKN1B ELISA Kits) represents a crucial node in the network integrating patterning information and cell cycle regulation that underlies growth, differentiation, and branching morphogenesis of this organ.
an unanticipated link between TBX2 deregulation in cancer and the acquisition of EMT (zeige ITK ELISA Kits) and invasive features of epithelial tumor cells.
This study lays the foundation for investigation of functional requirements for Tbx2 subfamily genes in development of the mammalian reproductive system.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.
T-Box protein 2
, T-box transcription factor TBX2-A
, T-box protein 2-A
, T-box transcription factor Tbx2
, T-box gene C
, T-box protein 2b
, T-box transcription factor TBX2b
, T-box 2
, T-box transcription factor 2
, T-box transcription factor TBX2-like
, T-box transcription factor TBX2
, T-box 2 protein
, T-box protein 2
, T-box 2 transcription factor